Synthesis of 8',11'-dihydrospiro[cyclohexane-1,2'-oxepino[2,3-] Chromen]-4'(3')-ones with Ring Closing Metathesis As a Key Step

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2022 May 13

PMID 35559090

Authors

Prathima K

Ashok D

Sarasija M

Prabhakar Sripadi

Madhu Vemula

Venkata S Komarraju

Biswajit Gorai

Shyam Prakash

Affiliations

Soon will be listed here.

Abstract

A series of novel hybrid molecular entities incorporating various spiro chromanone scaffolds onto the benzannulated oxepine core moiety were synthesised using allylation, Claisen rearrangement, Kabbe condensation and Ring Closing Metathesis (RCM) as a key step. During the synthesis we found that the nitrogen functionality in the substrate influences significantly the catalyst load due to electronic effects. Several iterations have been carried out to achieve complete conversion to products 6a-6e.

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