An Iodine/DMSO-catalyzed Sequential One-pot Approach to 2,4,5-trisubstituted-1-imidazoles from α-methylene Ketones

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2022 May 13

PMID 35558600

Authors

Janeeka Jayram

Vineet Jeena

Affiliations

Soon will be listed here.

Abstract

A sequential one-pot approach to 2,4,5-trisubstituted imidazoles has been developed from α-methylene ketones and aldehydes. This methodology employs air-moisture stable reaction conditions and an inexpensive iodine/DMSO system affording a diverse range of known and novel (substrate scope) 2,4,5-trisubstituted imidazoles in moderate to excellent yields. The iodine/DMSO system was extended to the domino convergent synthesis of two functionalized intermediates, benzil and benzaldehyde, to produce the final product.

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