Can Neuropeptide S Be an Indicator for Assessing Anxiety in Psychiatric Disorders?

Overview

Journal Front Public Health

Specialty Public Health

Date 2022 May 13

PMID 35558538

Authors

Agnieszka Markiewicz-Gospodarek

Piotr Kuszta

Jacek Baj

Beata Dobrowolska

Renata Markiewicz

Affiliations

Soon will be listed here.

Abstract

Neuropeptide S (NPS) is a neuropeptide primarily produced within three brainstem regions including locus coeruleus, trigeminal nerve nucleus, and lateral parabrachial nucleus. NPS is involved in the central regulation of stress, fear, and cognitive integration. NPS is a mediator of behavior, seeking food, and the proliferation of new adipocytes in the setting of obesity. So far, current research of NPS is only limited to animal models; data regarding its functions in humans is still scarce. Animal studies showed that anxiety and appetite might be suppressed by the action of NPS. The discovery of this neuromodulator peptide is effective considering its strong anxiolytic action, which has the potential to be an interesting therapeutic option in treating neuropsychiatric disorders. In this article, we aimed to analyze the pharmaceutical properties of NPS as well as its influence on several neurophysiological aspects-modulation of behavior, association with obesity, as well as its potential application in rehabilitation and treatment of psychiatric disorders.

Citing Articles

Relationship of Neuropeptide S (NPS) with Neurocognitive, Clinical, and Electrophysiological Parameters of Patients during Structured Rehabilitation Therapy for Schizophrenia.

Markiewicz-Gospodarek A, Markiewicz R, Dobrowolska B, Rahnama M, Loza B J Clin Med. 2022; 11(18).

PMID: 36142912 PMC: 9506378. DOI: 10.3390/jcm11185266.

Relationship of Neuropeptide S with Clinical and Metabolic Parameters of Patients during Rehabilitation Therapy for Schizophrenia.

Markiewicz-Gospodarek A, Markiewicz R, Dobrowolska B, Maciejewski R, Loza B Brain Sci. 2022; 12(6).

PMID: 35741653 PMC: 9221542. DOI: 10.3390/brainsci12060768.

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