Potential Mechanisms and Therapeutic Targets of Mesenchymal Stem Cell Transplantation for Ischemic Stroke

Overview

Journal Stem Cell Res Ther

Publisher Biomed Central

Date 2022 May 13

PMID 35551643

Authors

Li Zhou

Huimin Zhu

Xue Bai

Jiagui Huang

Yue Chen

Jun Wen

Xuemei Li

Bowen Wu

Yongjun Tan

Mingfen Tian

Jiangxia Ren

Mengxia Li

Qin Yang

Affiliations

Soon will be listed here.

Abstract

Ischemic stroke is one of the major causes of death and disability in the world. Currently, most patients cannot choose intravenous thrombolysis or intravascular mechanical thrombectomy because of narrow therapeutic windows and severe complications. Stem cell transplantation is an emerging treatment and has been studied in various central nervous system diseases. Animal and clinical studies showed that transplantation of mesenchymal stem cells (MSCs) could alleviate neurological deficits and bring hope for ischemic stroke treatment. This article reviewed biological characteristics, safety, feasibility and efficacy of MSCs therapy, potential therapeutic targets of MSCs, and production process of Good Manufacturing Practices-grade MSCs, to explore the potential therapeutic targets of MSCs in the process of production and use and provide new therapeutic directions for ischemic stroke.

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