3D Chromosomal Architecture in Germinal Center B Cells and Its Alterations in Lymphomagenesis

Overview

Journal Curr Opin Genet Dev

Publisher Elsevier

Specialties Biology
Genetics

Date 2022 May 13

PMID 35550952

Authors

Antonin Papin

Ethel Cesarman

Ari Melnick

Affiliations

Soon will be listed here.

Abstract

In eukaryotic cells, the genome is three dimensionally (3D) organized with DNA interaction dynamics and topology changes that regulate gene expression and drive cell fate. Upon antigen stimulation, naive B cells are activated and form germinal centers (GC) for the generation of memory B cells and plasma cells. Thereby, terminal B-cell differentiation and associated humoral immune response require massive but rigorous 3D DNA reorganization. Here, we review the dynamics of genome reorganization during GC formation and the impact of its alterations on lymphomagenesis from the nucleosome structure to the higher order chromosome organization. We particularly discuss the identified architects of 3D DNA in GC B cells and the role of their mutations in B-cell lymphomas.

Citing Articles

SMARCA5-mediated chromatin remodeling is required for germinal center formation.

Stoler-Barak L, Schmiedel D, Sarusi-Portuguez A, Rogel A, Blecher-Gonen R, Haimon Z J Exp Med. 2024; 221(11).

PMID: 39297882 PMC: 11413417. DOI: 10.1084/jem.20240433.

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