Neuropathology of Parkinson's Disease After Focused Ultrasound Thalamotomy

Overview

Journal NPJ Parkinsons Dis

Date 2022 May 13

PMID 35550514

Authors

Shunsuke Koga

Mariam Ishaque

W Jeffrey Elias

Binit B Shah

Aya Murakami

Dennis W Dickson

Affiliations

Soon will be listed here.

Abstract

Focused ultrasound (FUS) thalamotomy is an emerging treatment for tremor-dominant Parkinson's disease (PD). We report the first postmortem neuropathologic study of FUS thalamotomy in a 68-year-old man with tremor-dominant PD, which was performed seven months before he died. Although the peak voxel temperature at the target was <54 °C, his tremor improved on intraoperative and postoperative assessments. Additionally, postoperative MRI demonstrated a thalamic lesion. Lewy body-related pathology consistent with PD was detected. There was also a 5-mm lesion in the ventral lateral thalamus characterized by demyelination and neuropil loss, with many lipid-laden macrophages, but no lymphocytic infiltrates and relatively preserved neurons and axons. Additional pathological assessments after FUS thalamotomy are needed to determine if the observed brain changes are typical of this procedure.

Citing Articles

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Magnetic Resonance-Guided Focused Ultrasound Thalamotomy Rebalances Atypical Functional Hierarchy in Patients with Essential Tremor.

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