Therapeutic Targeting of the Respiratory Microbiome

Overview

Journal Am J Respir Crit Care Med

Specialty Critical Care

Date 2022 May 13

PMID 35549655

Authors

Sanjay H Chotirmall

Debby Bogaert

James D Chalmers

Michael J Cox

Philip M Hansbro

Yvonne J Huang

Philip L Molyneaux

David N ODwyer

Alexa A Pragman

Geraint B Rogers

Leopoldo N Segal

Robert P Dickson

Affiliations

Soon will be listed here.

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Microbial Buffer? The Human Lung Microbiome and Immune Responses to Diesel Exhaust.

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Infection and the microbiome in bronchiectasis.

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The Precision Medicine Era of Bronchiectasis.

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Pathobiological signatures of dysbiotic lung injury in pediatric patients undergoing stem cell transplantation.

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References

Segal L, Clemente J, Wu B, Wikoff W, Gao Z, Li Y . Randomised, double-blind, placebo-controlled trial with azithromycin selects for anti-inflammatory microbial metabolites in the emphysematous lung. Thorax. 2016; 72(1):13-22. PMC: 5329050. DOI: 10.1136/thoraxjnl-2016-208599. View

Wu B, Kapoor B, Cummings K, Stanton M, Nett R, Kreiss K . Evidence for Environmental-Human Microbiota Transfer at a Manufacturing Facility with Novel Work-related Respiratory Disease. Am J Respir Crit Care Med. 2020; 202(12):1678-1688. PMC: 7737585. DOI: 10.1164/rccm.202001-0197OC. View

Serisier D, Martin M, McGuckin M, Lourie R, Chen A, Brain B . Effect of long-term, low-dose erythromycin on pulmonary exacerbations among patients with non-cystic fibrosis bronchiectasis: the BLESS randomized controlled trial. JAMA. 2013; 309(12):1260-7. DOI: 10.1001/jama.2013.2290. View

Johnstone J, Meade M, Lauzier F, Marshall J, Duan E, Dionne J . Effect of Probiotics on Incident Ventilator-Associated Pneumonia in Critically Ill Patients: A Randomized Clinical Trial. JAMA. 2021; 326(11):1024-1033. PMC: 8456390. DOI: 10.1001/jama.2021.13355. View

Sulaiman I, Wu B, Li Y, Tsay J, Sauthoff M, Scott A . Functional lower airways genomic profiling of the microbiome to capture active microbial metabolism. Eur Respir J. 2021; 58(1). PMC: 8643072. DOI: 10.1183/13993003.03434-2020. View

Duan K, Dammel C, Stein J, Rabin H, Surette M . Modulation of Pseudomonas aeruginosa gene expression by host microflora through interspecies communication. Mol Microbiol. 2003; 50(5):1477-91. DOI: 10.1046/j.1365-2958.2003.03803.x. View

Bertelsen A, Elborn J, Schock B . Microbial interaction: Prevotella spp. reduce P. aeruginosa induced inflammation in cystic fibrosis bronchial epithelial cells. J Cyst Fibros. 2021; 20(4):682-691. DOI: 10.1016/j.jcf.2021.04.012. View

Varney V, Parnell H, Salisbury D, Ratnatheepan S, Tayar R . A double blind randomised placebo controlled pilot study of oral co-trimoxazole in advanced fibrotic lung disease. Pulm Pharmacol Ther. 2007; 21(1):178-87. DOI: 10.1016/j.pupt.2007.02.001. View

Brill S, Law M, El-Emir E, Allinson J, James P, Maddox V . Effects of different antibiotic classes on airway bacteria in stable COPD using culture and molecular techniques: a randomised controlled trial. Thorax. 2015; 70(10):930-8. PMC: 4602260. DOI: 10.1136/thoraxjnl-2015-207194. View

10.

Bowerman K, Rehman S, Vaughan A, Lachner N, Budden K, Kim R . Disease-associated gut microbiome and metabolome changes in patients with chronic obstructive pulmonary disease. Nat Commun. 2020; 11(1):5886. PMC: 7676259. DOI: 10.1038/s41467-020-19701-0. View

11.

Thorsen J, Stokholm J, Rasmussen M, Steen Mortensen M, Brejnrod A, Hjelmso M . The Airway Microbiota Modulates Effect of Azithromycin Treatment for Episodes of Recurrent Asthma-like Symptoms in Preschool Children: A Randomized Clinical Trial. Am J Respir Crit Care Med. 2021; 204(2):149-158. DOI: 10.1164/rccm.202008-3226OC. View

12.

Taylor S, Leong L, Mobegi F, Choo J, Wesselingh S, Yang I . Long-Term Azithromycin Reduces and Increases Antibiotic Resistance in Severe Asthma. Am J Respir Crit Care Med. 2019; 200(3):309-317. DOI: 10.1164/rccm.201809-1739OC. View

13.

Burr L, Rogers G, Chen A, Hamilton B, Pool G, Taylor S . Macrolide Treatment Inhibits Pseudomonas aeruginosa Quorum Sensing in Non-Cystic Fibrosis Bronchiectasis. An Analysis from the Bronchiectasis and Low-Dose Erythromycin Study Trial. Ann Am Thorac Soc. 2016; 13(10):1697-1703. DOI: 10.1513/AnnalsATS.201601-044OC. View

14.

Choo J, Abell G, Thomson R, Morgan L, Waterer G, Gordon D . Impact of Long-Term Erythromycin Therapy on the Oropharyngeal Microbiome and Resistance Gene Reservoir in Non-Cystic Fibrosis Bronchiectasis. mSphere. 2018; 3(2). PMC: 5907653. DOI: 10.1128/mSphere.00103-18. View

15.

Taylor S, Leong L, Ivey K, Wesselingh S, Grimwood K, Wainwright C . Total bacterial load, inflammation, and structural lung disease in paediatric cystic fibrosis. J Cyst Fibros. 2020; 19(6):923-930. DOI: 10.1016/j.jcf.2020.03.008. View

16.

Sibila O, Laserna E, Shoemark A, Keir H, Finch S, Rodrigo-Troyano A . Airway Bacterial Load and Inhaled Antibiotic Response in Bronchiectasis. Am J Respir Crit Care Med. 2019; 200(1):33-41. DOI: 10.1164/rccm.201809-1651OC. View

17.

Moore W, Meyers D, Wenzel S, Teague W, Li H, Li X . Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med. 2009; 181(4):315-23. PMC: 2822971. DOI: 10.1164/rccm.200906-0896OC. View

18.

ODwyer D, Ashley S, Gurczynski S, Xia M, Wilke C, Falkowski N . Lung Microbiota Contribute to Pulmonary Inflammation and Disease Progression in Pulmonary Fibrosis. Am J Respir Crit Care Med. 2019; 199(9):1127-1138. PMC: 6515865. DOI: 10.1164/rccm.201809-1650OC. View

19.

Combs M, Wheeler D, Luth J, Falkowski N, Walker N, Erb-Downward J . Lung microbiota predict chronic rejection in healthy lung transplant recipients: a prospective cohort study. Lancet Respir Med. 2021; 9(6):601-612. PMC: 8892628. DOI: 10.1016/S2213-2600(20)30405-7. View

20.

Wu B, Sulaiman I, Tsay J, Perez L, Franca B, Li Y . Episodic Aspiration with Oral Commensals Induces a MyD88-dependent, Pulmonary T-Helper Cell Type 17 Response that Mitigates Susceptibility to . Am J Respir Crit Care Med. 2020; 203(9):1099-1111. PMC: 8314894. DOI: 10.1164/rccm.202005-1596OC. View