Pathway-Based Analysis Revealed the Role of Keap1-Nrf2 Pathway and PI3K-Akt Pathway in Chinese Esophageal Squamous Cell Carcinoma Patients With Definitive Chemoradiotherapy

Overview

Journal Front Genet

Date 2022 May 13

PMID 35548450

Authors

Honghai Dai

Yanjun Wei

Yunxia Liu

Jingwen Liu

Ruoying Yu

Junli Zhang

Jiaohui Pang

Yang Shao

Qiang Li

Zhe Yang

Affiliations

Soon will be listed here.

Abstract

Esophageal squamous cell carcinoma (ESCC) is the major type of EC in China. Chemoradiotherapy is a standard definitive treatment for early-stage EC and significantly improves local control and overall survival for late-stage patients. However, chemoradiotherapy resistance, which limits therapeutic efficacy and treatment-induced toxicity, is still a leading problem for treatment break. To optimize the selection of ESCC patients for chemoradiotherapy, we retrospectively analyzed the clinical features and genome landscape of a Chinese ESCC cohort of 58 patients. was the most frequent mutation gene, followed by . Frequently, copy number variants were found in (24/58, 41.4%), (23/58, 39.7%), (22/58, 37.9%), and (20/58, 34.5%). and amplifications were mutually exclusive in this cohort. Using univariate and multivariate analyses, the variant and mutant were identified as adverse factors for OS. Patients with - pathway alterations displayed longer PFS and OS than patients with an intact - pathway. On the contrary, two patients with - pathway alterations displayed significantly shortened PFS and OS, which may be associated with dCRT resistance. Our data highlighted the prognostic value of aberrant cancer pathways in ESCC patients, which may provide guidance for better chemoradiotherapy management.

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