Role of High-mobility Group Box 1 in Cancer

Overview

Journal Zhong Nan Da Xue Xue Bao Yi Xue Ban

Specialty General Medicine

Date 2022 May 11

PMID 35545346

Authors

Juan Xu

Pengzuo Tao

Dongjin Lu

Yue Jiang

Quansong Xia

Affiliations

Soon will be listed here.

Abstract

High-mobility group box 1 (HMGB1) is a non-histone nuclear protein in most eukaryocytes. Inside the nucleus, HMGB1 plays an important role in several DNA events such as DNA repair, transcription, telomere maintenance, and genome stability. While outside the nucleus, it fulfils more complicated functions, including promoting cell proliferation, inflammation, angiogenesis, immune tolerance and immune escape, which may play a pro-tumoral role.Meanwhile, HMGB1 acts as an anti-tumoral protein by regulating immune cell recruitment and inducing immunogenic cell death (ICD) during the carcinogenesis process. Therefore, abnormal expression of HMGB1 is associated with oncogenesis, development, and metastasis of cancer, which may play a dual role of pro-tumor and anti-tumor.

Citing Articles

USP15 promotes the progression of papillary thyroid cancer by regulating HMGB1 stability through its deubiquitination.

Wang S, Ye D, Wang B, Li M, Zhao W J Cancer. 2024; 15(9):2561-2572.

PMID: 38577597 PMC: 10988300. DOI: 10.7150/jca.92386.

Advanced Biomarkers of Hepatotoxicity in Psychiatry: A Narrative Review and Recommendations for New Psychoactive Substances.

Golub A, Ordak M, Nasierowski T, Bujalska-Zadrozny M Int J Mol Sci. 2023; 24(11).

PMID: 37298365 PMC: 10253383. DOI: 10.3390/ijms24119413.

References

Gao Q, Li F, Wang S, Shen Z, Cheng S, Ping Y . A cycle involving HMGB1, IFN-γ and dendritic cells plays a putative role in anti-tumor immunity. Cell Immunol. 2018; 343:103850. DOI: 10.1016/j.cellimm.2018.08.011. View

Parker K, Sinha P, Horn L, Clements V, Yang H, Li J . HMGB1 enhances immune suppression by facilitating the differentiation and suppressive activity of myeloid-derived suppressor cells. Cancer Res. 2014; 74(20):5723-33. PMC: 4199911. DOI: 10.1158/0008-5472.CAN-13-2347. View

Germann M, Zangger N, Sauvain M, Sempoux C, Bowler A, Wirapati P . Neutrophils suppress tumor-infiltrating T cells in colon cancer via matrix metalloproteinase-mediated activation of TGFβ. EMBO Mol Med. 2019; 12(1):e10681. PMC: 6949488. DOI: 10.15252/emmm.201910681. View

Lindner S, Dahlke K, Sontheimer K, Hagn M, Kaltenmeier C, Barth T . Interleukin 21-induced granzyme B-expressing B cells infiltrate tumors and regulate T cells. Cancer Res. 2013; 73(8):2468-79. DOI: 10.1158/0008-5472.CAN-12-3450. View

Lee H, Kim A, Song I, Park I, Yu J, Ahn J . Cytoplasmic expression of high mobility group B1 (HMGB1) is associated with tumor-infiltrating lymphocytes (TILs) in breast cancer. Pathol Int. 2016; 66(4):202-9. DOI: 10.1111/pin.12393. View

Polanska E, Dobsakova Z, Dvorackova M, Fajkus J, Stros M . HMGB1 gene knockout in mouse embryonic fibroblasts results in reduced telomerase activity and telomere dysfunction. Chromosoma. 2012; 121(4):419-31. DOI: 10.1007/s00412-012-0373-x. View

Su Z, Ni P, She P, Liu Y, Richard S, Xu W . Bio-HMGB1 from breast cancer contributes to M-MDSC differentiation from bone marrow progenitor cells and facilitates conversion of monocytes into MDSC-like cells. Cancer Immunol Immunother. 2016; 66(3):391-401. PMC: 11028758. DOI: 10.1007/s00262-016-1942-2. View

He Y, Zha J, Wang Y, Liu W, Yang X, Yu P . Tissue damage-associated "danger signals" influence T-cell responses that promote the progression of preneoplasia to cancer. Cancer Res. 2012; 73(2):629-39. DOI: 10.1158/0008-5472.CAN-12-2704. View

Zuo Z, Che X, Wang Y, Li B, Li J, Dai W . High mobility group Box-1 inhibits cancer cell motility and metastasis by suppressing activation of transcription factor CREB and nWASP expression. Oncotarget. 2014; 5(17):7458-70. PMC: 4202136. DOI: 10.18632/oncotarget.2150. View

10.

Pan B, Chen D, Huang J, Wang R, Feng B, Song H . HMGB1-mediated autophagy promotes docetaxel resistance in human lung adenocarcinoma. Mol Cancer. 2014; 13:165. PMC: 4125709. DOI: 10.1186/1476-4598-13-165. View

11.

Yang Z, Guo J, Weng L, Tang W, Jin S, Ma W . Myeloid-derived suppressor cells-new and exciting players in lung cancer. J Hematol Oncol. 2020; 13(1):10. PMC: 6995114. DOI: 10.1186/s13045-020-0843-1. View

12.

Wang X, Zhang S, Shi M, Xu X . HMGB1 Promotes the Proliferation and Metastasis of Lung Cancer by Activating the Wnt/β-Catenin Pathway. Technol Cancer Res Treat. 2020; 19:1533033820948054. PMC: 7444109. DOI: 10.1177/1533033820948054. View

13.

Zhang Y, Gallastegui N, Rosenblatt J . Regulatory B cells in anti-tumor immunity. Int Immunol. 2015; 27(10):521-30. DOI: 10.1093/intimm/dxv034. View

14.

Kepp O, Senovilla L, Vitale I, Vacchelli E, Adjemian S, Agostinis P . Consensus guidelines for the detection of immunogenic cell death. Oncoimmunology. 2015; 3(9):e955691. PMC: 4292729. DOI: 10.4161/21624011.2014.955691. View

15.

Khambu B, Huda N, Chen X, Antoine D, Li Y, Dai G . HMGB1 promotes ductular reaction and tumorigenesis in autophagy-deficient livers. J Clin Invest. 2018; 128(6):2419-2435. PMC: 5983330. DOI: 10.1172/JCI91814. View

16.

Zhang Y, Ning B . Signaling pathways and intervention therapies in sepsis. Signal Transduct Target Ther. 2021; 6(1):407. PMC: 8613465. DOI: 10.1038/s41392-021-00816-9. View

17.

Barreiro-Alonso A, Camara-Quilez M, Salamini-Montemurri M, Lamas-Maceiras M, Vizoso-Vazquez A, Rodriguez-Belmonte E . Characterization of HMGB1/2 Interactome in Prostate Cancer by Yeast Two Hybrid Approach: Potential Pathobiological Implications. Cancers (Basel). 2019; 11(11). PMC: 6895793. DOI: 10.3390/cancers11111729. View

18.

Chen Y, Cai L, Guo X, Li Z, Liao X, Zhang X . HMGB1-activated fibroblasts promote breast cancer cells metastasis via RAGE/aerobic glycolysis. Neoplasma. 2020; 68(1):71-78. DOI: 10.4149/neo_2020_200610N620. View

19.

Tang D, Kang R, Zeh 3rd H, Lotze M . High-mobility group box 1, oxidative stress, and disease. Antioxid Redox Signal. 2010; 14(7):1315-35. PMC: 3048826. DOI: 10.1089/ars.2010.3356. View

20.

Li B, Song T, Wang F, Yin C, Li Z, Lin J . Tumor-derived exosomal HMGB1 promotes esophageal squamous cell carcinoma progression through inducing PD1 TAM expansion. Oncogenesis. 2019; 8(3):17. PMC: 6386749. DOI: 10.1038/s41389-019-0126-2. View