DNA-induced Synthesis of Biomimetic Enzyme for Sensitive Detection of Superoxide Anions Released from Live Cell

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2022 May 11

PMID 35539377

Authors

Ailing Ding

Bin Wang

Xiaoqing Ma

Jianglin Diao

Jiushang Zheng

Jiucun Chen

Changming Li

Affiliations

Soon will be listed here.

Abstract

In this work, we successfully fabricate a rapid, sensitive sensor for the detection of superoxide anions O˙ based on graphene/DNA/Mn(PO) biomimetic enzyme. In the design, graphene is served as excellent carrier to improve the catalysis of Mn(PO) nanoparticles; and DNA adsorbed on graphene acts as medium to assist the growth of Mn(PO) on graphene. The fabricated graphene/DNA/Mn(PO) composites exhibit excellently electrochemical activity, significantly decrease the response time and increase the sensitivity of the sensor towards O˙. The successful detection of O˙ released from cancer cell demonstrated its potential applications in biology and medicine.

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