A Newly Isolated Human Intestinal Strain Deglycosylating Flavonoid C-glycosides

Overview

Journal Arch Microbiol

Specialty Microbiology

Date 2022 May 10

PMID 35536516

Authors

Sha Wang

Siqi Liu

Jing Wang

Jiayue Tao

Mengjiao Wu

Wenfu Ma

Rufeng Wang

Affiliations

Soon will be listed here.

Abstract

Glycosidic bond of C-glycosides is difficult to be broken due to its chemical stability. Screening specific microbe from microbiota is a practical way to deglycosylate these compounds. In this study, a new strain W974-1 which is capable of cleaving C-glycosidic bonds was isolated from human gut microbiota by spread plate method. It deglycosylates flavonoid 8-C-glycosides such as orientin and vitexin to their aglycones with the enzymes secreted outside the bacterial cells. This strain was identified as Enterococcus avium by 16S rDNA sequencing, physiological and biochemical characterization.

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