» Articles » PMID: 35536161

Clinical Perspectives on Vagus Nerve Stimulation: Present and Future

Overview
Journal Clin Sci (Lond)
Date 2022 May 10
PMID 35536161
Authors
Affiliations
Soon will be listed here.
Abstract

The vagus nerve, the great wanderer, is involved in numerous processes throughout the body and vagus nerve stimulation (VNS) has the potential to modulate many of these functions. This wide-reaching capability has generated much interest across a range of disciplines resulting in several clinical trials and studies into the mechanistic basis of VNS. This review discusses current preclinical and clinical evidence supporting the efficacy of VNS in different diseases and highlights recent advancements. Studies that provide insights into the mechanism of VNS are considered.

Citing Articles

Interaction of the Vagus Nerve and Serotonin in the Gut-Brain Axis.

Hwang Y, Oh J Int J Mol Sci. 2025; 26(3).

PMID: 39940928 PMC: 11818468. DOI: 10.3390/ijms26031160.


Mechanisms of vagus nerve stimulation for the treatment of neurodevelopmental disorders: a focus on microglia and neuroinflammation.

Gargus M, Ben-Azu B, Landwehr A, Dunn J, Errico J, Tremblay M Front Neurosci. 2025; 18:1527842.

PMID: 39881804 PMC: 11774973. DOI: 10.3389/fnins.2024.1527842.


Transcutaneous vagus nerve stimulation for Parkinson's disease: a systematic review and meta-analysis.

Shan J, Li Z, Ji M, Zhang M, Zhang C, Zhu Y Front Aging Neurosci. 2025; 16:1498176.

PMID: 39877075 PMC: 11772336. DOI: 10.3389/fnagi.2024.1498176.


Noninvasive Vagus Nerve Stimulation Protects Neurons in the Perihematomal Region and Improves the Outcomes in a Rat Model of Intracerebral Hemorrhage.

Caceres E, Salazar P, Shidoh S, Ortiz M, Bragin D, Kibria F Neurocrit Care. 2025; .

PMID: 39815107 DOI: 10.1007/s12028-024-02195-9.


A Flexible, Implantable, Bioelectronic Electroporation Device for Targeted Ablation of Seizure Foci in the Mouse Brain.

Matta R, Balogh-Lantos Z, Fekete Z, Baca M, Kaszas A, Moreau D Sensors (Basel). 2025; 25(1.

PMID: 39796794 PMC: 11722952. DOI: 10.3390/s25010004.


References
1.
Machhada A, Trapp S, Marina N, Stephens R, Whittle J, Lythgoe M . Vagal determinants of exercise capacity. Nat Commun. 2017; 8:15097. PMC: 5454375. DOI: 10.1038/ncomms15097. View

2.
Englot D, Chang E, Auguste K . Efficacy of vagus nerve stimulation for epilepsy by patient age, epilepsy duration, and seizure type. Neurosurg Clin N Am. 2011; 22(4):443-8, v. DOI: 10.1016/j.nec.2011.07.002. View

3.
Payne S, Furness J, Stebbing M . Bioelectric neuromodulation for gastrointestinal disorders: effectiveness and mechanisms. Nat Rev Gastroenterol Hepatol. 2018; 16(2):89-105. DOI: 10.1038/s41575-018-0078-6. View

4.
Kaniusas E, Kampusch S, Tittgemeyer M, Panetsos F, Gines R, Papa M . Current Directions in the Auricular Vagus Nerve Stimulation I - A Physiological Perspective. Front Neurosci. 2019; 13:854. PMC: 6697069. DOI: 10.3389/fnins.2019.00854. View

5.
Kuwabara S, Goggins E, Tanaka S . Neuroimmune Circuits Activated by Vagus Nerve Stimulation. Nephron. 2021; 146(3):286-290. DOI: 10.1159/000518176. View