Human Umbilical Cord-derived Mesenchymal Stem Cells Promote Repair of Neonatal Brain Injury Caused by Hypoxia/ischemia in Rats

Overview

Journal Neural Regen Res

Date 2022 May 10

PMID 35535905

Authors

Yang Jiao

Yue-Tong Sun

Nai-Fei Chen

Li-Na Zhou

Xin Guan

Jia-Yi Wang

Wen-Juan Wei

Chao Han

Xiao-Lei Jiang

Ya-Chen Wang

Wei Zou

Jing Liu

Affiliations

Soon will be listed here.

Abstract

Administration of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) is believed to be an effective method for treating neurodevelopmental disorders. In this study, we investigated the possibility of hUC-MSCs treatment of neonatal hypoxic/ischemic brain injury associated with maternal immune activation and the underlying mechanism. We established neonatal rat models of hypoxic/ischemic brain injury by exposing pregnant rats to lipopolysaccharide on day 16 or 17 of pregnancy. Rat offspring were intranasally administered hUC-MSCs on postnatal day 14. We found that polypyrimidine tract-binding protein-1 (PTBP-1) participated in the regulation of lipopolysaccharide-induced maternal immune activation, which led to neonatal hypoxic/ischemic brain injury. Intranasal delivery of hUC-MSCs inhibited PTBP-1 expression, alleviated neonatal brain injury-related inflammation, and regulated the number and function of glial fibrillary acidic protein-positive astrocytes, thereby promoting plastic regeneration of neurons and improving brain function. These findings suggest that hUC-MSCs can effectively promote the repair of neonatal hypoxic/ischemic brain injury related to maternal immune activation through inhibition of PTBP-1 expression and astrocyte activation.

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