Evaluation of Inactivated COVID-19 Vaccine on Semen Parameters in Reproductive-age Males: a Retrospective Cohort Study

Overview

Journal Asian J Androl

Specialty Urology

Date 2022 May 9

PMID 35532560

Authors

Hong Zhu

Xiao Wang

Feng Zhang

Yong Zhu

Mei-Rong Du

Zhi-Wen Tao

Can Sun

Hai-Tao Ma

Ya-Dong Li

Guo-Qing Liang

Jie Ren

Bai-Lan Feng

Feng Jiang

Affiliations

Soon will be listed here.

Abstract

During the coronavirus disease (COVID-19) epidemic, there have been concerns about the impact of vaccines on people's fertility, including the fertility of those who are currently preparing for pregnancy and those who might become pregnant in future. However, there is still a lack of research on the effect of the COVID-19 vaccine on male fertility, and it is not surprising that couples and donors have concerns regarding vaccination. In this study, a retrospective cohort study was conducted to examine semen quality before and after receipt of the inactivated COVID-19 vaccine. There were no statistically significant changes in semen parameters (volume, sperm concentration, progressive motility, and total progressive motile count) after two doses of vaccine (all P > 0.05). In summary, our study updates the most recent studies on the effects of the COVID-19 vaccine on male fertility, and the information from this study could be used to guide fertility recommendations for assisted reproductive technology (ART) patients and donors.

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References

Veiga A, Gianaroli L, Ory S, Horton M, Feinberg E, Penzias A . Assisted reproduction and COVID-19: A joint statement of ASRM, ESHRE and IFFS. Fertil Steril. 2020; 114(3):484-485. PMC: 7355315. DOI: 10.1016/j.fertnstert.2020.06.044. View

Wang Z, Xu X . scRNA-seq Profiling of Human Testes Reveals the Presence of the ACE2 Receptor, A Target for SARS-CoV-2 Infection in Spermatogonia, Leydig and Sertoli Cells. Cells. 2020; 9(4). PMC: 7226809. DOI: 10.3390/cells9040920. View

Oliver S, Gargano J, Marin M, Wallace M, Curran K, Chamberland M . The Advisory Committee on Immunization Practices' Interim Recommendation for Use of Pfizer-BioNTech COVID-19 Vaccine - United States, December 2020. MMWR Morb Mortal Wkly Rep. 2020; 69(50):1922-1924. PMC: 7745957. DOI: 10.15585/mmwr.mm6950e2. View

He Y, Wang J, Ren J, Zhao Y, Chen J, Chen X . Effect of COVID-19 on Male Reproductive System - A Systematic Review. Front Endocrinol (Lausanne). 2021; 12:677701. PMC: 8190708. DOI: 10.3389/fendo.2021.677701. View

Holtmann N, Edimiris P, Andree M, Doehmen C, Baston-Buest D, Adams O . Assessment of SARS-CoV-2 in human semen-a cohort study. Fertil Steril. 2020; 114(2):233-238. PMC: 7256599. DOI: 10.1016/j.fertnstert.2020.05.028. View

Gonzalez D, Nassau D, Khodamoradi K, Ibrahim E, Blachman-Braun R, Ory J . Sperm Parameters Before and After COVID-19 mRNA Vaccination. JAMA. 2021; 326(3):273-274. PMC: 8293015. DOI: 10.1001/jama.2021.9976. View

Sergerie M, Mieusset R, Croute F, Daudin M, Bujan L . High risk of temporary alteration of semen parameters after recent acute febrile illness. Fertil Steril. 2007; 88(4):970.e1-7. DOI: 10.1016/j.fertnstert.2006.12.045. View

Guo T, Sang M, Bai S, Ma H, Wan Y, Jiang X . Semen parameters in men recovered from COVID-19. Asian J Androl. 2021; 23(5):479-483. PMC: 8451500. DOI: 10.4103/aja.aja_31_21. View

Yan R, Zhang Y, Li Y, Xia L, Guo Y, Zhou Q . Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. Science. 2020; 367(6485):1444-1448. PMC: 7164635. DOI: 10.1126/science.abb2762. View

10.

Graham B . Rapid COVID-19 vaccine development. Science. 2020; 368(6494):945-946. DOI: 10.1126/science.abb8923. View

11.

Maertens K, Orije M, Van Damme P, Leuridan E . Vaccination during pregnancy: current and possible future recommendations. Eur J Pediatr. 2020; 179(2):235-242. PMC: 7222942. DOI: 10.1007/s00431-019-03563-w. View

12.

Huang C, Zhou S, Gao L, Li S, Cheng Y, Zhou W . Risks associated with cryopreserved semen in a human sperm bank during and after the COVID-19 pandemic. Reprod Biomed Online. 2021; 42(3):589-594. PMC: 7713547. DOI: 10.1016/j.rbmo.2020.11.015. View

13.

Groner M, de Carvalho R, Camillo J, Ferreira P, Fraietta R . Effects of Covid-19 on male reproductive system. Int Braz J Urol. 2020; 47(1):185-190. PMC: 7712710. DOI: 10.1590/S1677-5538.IBJU.2021.99.04. View

14.

Ping P, Zhu W, Zhang X, Li Y, Wang Q, Cao X . Sperm donation and its application in China: a 7-year multicenter retrospective study. Asian J Androl. 2011; 13(4):644-8. PMC: 3739624. DOI: 10.1038/aja.2011.20. View

15.

Temiz M, Dincer M, Hacibey I, Yazar R, Celik C, Kucuk S . Investigation of SARS-CoV-2 in semen samples and the effects of COVID-19 on male sexual health by using semen analysis and serum male hormone profile: A cross-sectional, pilot study. Andrologia. 2020; 53(2):e13912. PMC: 7744846. DOI: 10.1111/and.13912. View

16.

Lo S, Hsieh T, Pastuszak A, Hotaling J, Patel D . Effects of SARS CoV-2, COVID-19, and its vaccines on male sexual health and reproduction: where do we stand?. Int J Impot Res. 2021; 34(2):138-144. PMC: 8548269. DOI: 10.1038/s41443-021-00483-y. View

17.

Lawson A, McQueen D, Swanson A, Confino R, Feinberg E, Pavone M . Psychological distress and postponed fertility care during the COVID-19 pandemic. J Assist Reprod Genet. 2021; 38(2):333-341. PMC: 7783482. DOI: 10.1007/s10815-020-02023-x. View