The Role of Fbxo5 in the Development of Human Malignant Tumors

Overview

Journal Am J Cancer Res

Specialty Oncology

Date 2022 May 9

PMID 35530293

Authors

Junjie Gao

Dandan Yang

Ruoxue Cao

Hua Huang

Jia Ma

Zhiwei Wang

Jun Xia

Xueshan Pan

Affiliations

Soon will be listed here.

Abstract

Fbxo5 (F-Box only protein 5), as a substrate recognition subunit of SCF (SKP1-Cullin1-Fbox) protein, plays a crucial role in various cellular processes through ubiquitination and degradation of multiple proteins. In recent years, many studies have pointed out that Fbxo5 is critically involved in carcinogenesis. Moreover, targeting Fbxo5 could have a therapeutic potential for cancer therapy. This review focuses on the functions of Fbxo5 in various types of human malignancies and its underlying molecular mechanisms. This review might lay the foundation for enhancing future investigation on Fbxo5 functions in cancer development and progression.

Citing Articles

Implications of the NDC80 complex on the tumor immune microenvironment and cell growth in pan-cancer.

Wang J, Diao T, Yang X, Li K, Yang J, Chen X J Cancer. 2024; 15(19):6364-6382.

PMID: 39513104 PMC: 11540516. DOI: 10.7150/jca.96070.

CDK4/6 inhibition initiates cell cycle arrest by nuclear translocation of RB and induces a multistep molecular response.

Hong T, Hogger A, Wang D, Pan Q, Gansel J, Engleitner T Cell Death Discov. 2024; 10(1):453.

PMID: 39461947 PMC: 11513128. DOI: 10.1038/s41420-024-02218-6.

FBXO family genes promotes hepatocellular carcinoma via ubiquitination of p53.

Gong Q, Zhang L, Guo J, Zhao W, Zhou B, Yang C J Cancer Res Clin Oncol. 2024; 150(10):458.

PMID: 39397119 PMC: 11471714. DOI: 10.1007/s00432-024-05948-3.

Kidney Cancer Biomarker Selection Using Regularized Survival Models.

Peixoto C, Martins M, Costa L, Vinga S Cells. 2022; 11(15).

PMID: 35954157 PMC: 9367278. DOI: 10.3390/cells11152311.

The functions of long noncoding RNAs on regulation of F-box proteins in tumorigenesis and progression.

Xia L, Chen J, Huang M, Mei J, Lin M Front Oncol. 2022; 12:963617.

PMID: 35928868 PMC: 9343830. DOI: 10.3389/fonc.2022.963617.

References

Zhao Y, Tang Q, Ni R, Huang X, Wang Y, Lu C . Early mitotic inhibitor-1, an anaphase-promoting complex/cyclosome inhibitor, can control tumor cell proliferation in hepatocellular carcinoma: correlation with Skp2 stability and degradation of p27(Kip1). Hum Pathol. 2012; 44(3):365-73. DOI: 10.1016/j.humpath.2012.03.030. View

Vaidyanathan S, Cato K, Tang L, Pavey S, Haass N, Gabrielli B . In vivo overexpression of Emi1 promotes chromosome instability and tumorigenesis. Oncogene. 2016; 35(41):5446-5455. DOI: 10.1038/onc.2016.94. View

Friedlaender A, Banna G, Malapelle U, Pisapia P, Addeo A . Next Generation Sequencing and Genetic Alterations in Squamous Cell Lung Carcinoma: Where Are We Today?. Front Oncol. 2019; 9:166. PMC: 6433884. DOI: 10.3389/fonc.2019.00166. View

Deshaies R, Joazeiro C . RING domain E3 ubiquitin ligases. Annu Rev Biochem. 2009; 78:399-434. DOI: 10.1146/annurev.biochem.78.101807.093809. View

Lehman N, Tibshirani R, Hsu J, Natkunam Y, Harris B, West R . Oncogenic regulators and substrates of the anaphase promoting complex/cyclosome are frequently overexpressed in malignant tumors. Am J Pathol. 2007; 170(5):1793-805. PMC: 1854971. DOI: 10.2353/ajpath.2007.060767. View

Shimizu N, Nakajima N, Tsunematsu T, Ogawa I, Kawai H, Hirayama R . Selective enhancing effect of early mitotic inhibitor 1 (Emi1) depletion on the sensitivity of doxorubicin or X-ray treatment in human cancer cells. J Biol Chem. 2013; 288(24):17238-52. PMC: 3682528. DOI: 10.1074/jbc.M112.446351. View

Liu Y, Pan B, Qu W, Cao Y, Li J, Zhao H . Systematic analysis of the expression and prognosis relevance of FBXO family reveals the significance of FBXO1 in human breast cancer. Cancer Cell Int. 2021; 21(1):130. PMC: 7903729. DOI: 10.1186/s12935-021-01833-y. View

Gutgemann I, Lehman N, Jackson P, Longacre T . Emi1 protein accumulation implicates misregulation of the anaphase promoting complex/cyclosome pathway in ovarian clear cell carcinoma. Mod Pathol. 2008; 21(4):445-54. DOI: 10.1038/modpathol.3801022. View

Schweikl H, Hiller K, Eckhardt A, Bolay C, Spagnuolo G, Stempfl T . Differential gene expression involved in oxidative stress response caused by triethylene glycol dimethacrylate. Biomaterials. 2008; 29(10):1377-87. DOI: 10.1016/j.biomaterials.2007.11.049. View

10.

Lin M, Xu Y, Gao Y, Pan C, Zhu X, Wang Z . Regulation of F-box proteins by noncoding RNAs in human cancers. Cancer Lett. 2019; 466:61-70. DOI: 10.1016/j.canlet.2019.09.008. View

11.

Penter L, Maier B, Frede U, Hackner B, Carell T, Hagemeier C . A rapid screening system evaluates novel inhibitors of DNA methylation and suggests F-box proteins as potential therapeutic targets for high-risk neuroblastoma. Target Oncol. 2015; 10(4):523-33. DOI: 10.1007/s11523-014-0354-5. View

12.

Moshe Y, Bar-On O, Ganoth D, Hershko A . Regulation of the action of early mitotic inhibitor 1 on the anaphase-promoting complex/cyclosome by cyclin-dependent kinases. J Biol Chem. 2011; 286(19):16647-57. PMC: 3089507. DOI: 10.1074/jbc.M111.223339. View

13.

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M . Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2014; 136(5):E359-86. DOI: 10.1002/ijc.29210. View

14.

Min K, Park M, Hong S, Lee H, Kwon S, Hong S . Clear cell carcinomas of the ovary: a multi-institutional study of 129 cases in Korea with prognostic significance of Emi1 and Galectin-3. Int J Gynecol Pathol. 2012; 32(1):3-14. DOI: 10.1097/PGP.0b013e31825554e9. View

15.

Zhao Q, Li H, Zhu L, Hu S, Xi X, Liu Y . Bioinformatics analysis shows that TOP2A functions as a key candidate gene in the progression of cervical cancer. Biomed Rep. 2020; 13(4):21. PMC: 7403841. DOI: 10.3892/br.2020.1328. View

16.

Kee Y, Huibregtse J . Regulation of catalytic activities of HECT ubiquitin ligases. Biochem Biophys Res Commun. 2007; 354(2):329-33. PMC: 2563040. DOI: 10.1016/j.bbrc.2007.01.025. View

17.

Yamano H . EMI1, a three-in-one ubiquitylation inhibitor. Nat Struct Mol Biol. 2013; 20(7):773-4. DOI: 10.1038/nsmb.2626. View

18.

Wang K, Qu X, Liu S, Yang X, Bie F, Wang Y . Identification of aberrantly expressed F-box proteins in squamous-cell lung carcinoma. J Cancer Res Clin Oncol. 2018; 144(8):1509-1521. DOI: 10.1007/s00432-018-2653-1. View

19.

Cardozo T, Pagano M . The SCF ubiquitin ligase: insights into a molecular machine. Nat Rev Mol Cell Biol. 2004; 5(9):739-51. DOI: 10.1038/nrm1471. View

20.

Yumimoto K, Yamauchi Y, Nakayama K . F-Box Proteins and Cancer. Cancers (Basel). 2020; 12(5). PMC: 7281081. DOI: 10.3390/cancers12051249. View