: A Phytochemical and Pharmacological Review

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2022 May 9

PMID 35529922

Authors

Tianyu Jin

Li Chi

Chongyang Ma

Affiliations

Soon will be listed here.

Abstract

Ledeb., which belongs to Agrimonia and Rosaceae, is used in traditional Chinese medicine. It exhibits excellent medicinal properties and has been used to treat various diseases, such as tumors, trichomoniasis, vaginitis, diarrhea, and dysentery. Phytochemical studies have revealed that has over 100 secondary metabolites that can be categorized into six classes, i.e., flavonoids, isocoumarins, triterpenes, phloroglucinol derivatives, tannins, and organic acids. This review summarizes recently published literature on the chemical structures of 90 bioactive compounds that have been identified in and examines their pharmacological properties, including their antitumor, anti-inflammatory, antioxidant, antibacterial, and antidiabetic properties, as well as the potential development of parasitic resistance to these chemicals. This review highlights existing knowledge gap and serves as a basis for developing novel preparations of with medicinal value.

Citing Articles

Preliminary Data on the Senolytic Effects of Ledeb. Extract Containing Agrimols for Immunosenescence in Middle-Aged Humans: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Comparison Study.

Shimizu Y, Shimodan S, Hayashida M, Yazaki M, Sakurada T, Watanabe T Nutrients. 2025; 17(4).

PMID: 40004995 PMC: 11858573. DOI: 10.3390/nu17040667.

Extract Exerts Its Therapeutic Effect through CRAC Channel Inhibition for Atopic Dermatitis Treatment.

Kim J, Lee J, Park S, Nam Y, Choi S, Nam J Int J Mol Sci. 2024; 25(16).

PMID: 39201579 PMC: 11355045. DOI: 10.3390/ijms25168894.

Medicinal flora of the baiku yao people - An ethnobotanical documentation in South China.

Li T, Luo B, Tong Y, Wei G, Chai L, Hu R BMC Complement Med Ther. 2024; 24(1):242.

PMID: 38907195 PMC: 11193194. DOI: 10.1186/s12906-024-04545-8.

Anti-Inflammatory Flavonoids from Ledeb: Focusing on Activity-Guided Isolation.

Park M, Ryu D, Cho J, Ku K, Kang Y Molecules. 2024; 29(2).

PMID: 38257196 PMC: 10819444. DOI: 10.3390/molecules29020283.

Current Progress and Outlook for Agrimonolide: A Promising Bioactive Compound from Ledeb.

Huang T, Zhao C, Xue M, Cao Y, Chen L, Chen J Pharmaceuticals (Basel). 2023; 16(2).

PMID: 37259301 PMC: 9960068. DOI: 10.3390/ph16020150.

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