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How Often is Each Gene Mutated Within the Cancer Patient Population?

Overview
Journal Mol Cell Oncol
Specialty Oncology
Date 2022 May 9
PMID 35529901
Authors
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Abstract

Genome sequenced samples from cancer patients helped identify roles of different mutation types and enabled targeted therapy development. However, critical questions like what are the gene mutation rates among the patients? or what genes are most commonly mutated, pan-cancer? have only been recently answered. Here, we highlight this recent advance.

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References
1.
Mendiratta G, Ke E, Aziz M, Liarakos D, Tong M, Stites E . Cancer gene mutation frequencies for the U.S. population. Nat Commun. 2021; 12(1):5961. PMC: 8514428. DOI: 10.1038/s41467-021-26213-y. View

2.
Merz V, Gaule M, Zecchetto C, Cavaliere A, Casalino S, Pesoni C . Targeting KRAS: The Elephant in the Room of Epithelial Cancers. Front Oncol. 2021; 11:638360. PMC: 7991835. DOI: 10.3389/fonc.2021.638360. View

3.
Cerami E, Gao J, Dogrusoz U, Gross B, Sumer S, Aksoy B . The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2012; 2(5):401-4. PMC: 3956037. DOI: 10.1158/2159-8290.CD-12-0095. View

4.
Sondka Z, Bamford S, Cole C, Ward S, Dunham I, Forbes S . The COSMIC Cancer Gene Census: describing genetic dysfunction across all human cancers. Nat Rev Cancer. 2018; 18(11):696-705. PMC: 6450507. DOI: 10.1038/s41568-018-0060-1. View

5.
. AACR Project GENIE: Powering Precision Medicine through an International Consortium. Cancer Discov. 2017; 7(8):818-831. PMC: 5611790. DOI: 10.1158/2159-8290.CD-17-0151. View