ZnBr/Oxone-mediated -cyclization of -(3-phenylprop-2-yn-1-yl)aniline

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2022 May 9

PMID 35529126

Authors

Keke Huang

Jia-Ni Li

Guanyinsheng Qiu

Wenlin Xie

Jin-Biao Liu

Affiliations

Soon will be listed here.

Abstract

In this work, a selective synthetic strategy towards 1-azaspiro[4.5]deca-3,6,9-trien-8-ones from -tosyl--(prop-2-yn-1-yl)aniline is developed. The transformation proceeds smoothly in a mixed solvent including acetonitrile and water when ZnBr and Oxone are employed. Mechanism studies show that the reaction proceeds in a regioselective manner a radical -cyclization pathway.

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