Functionalization of Theranostic AGuIX® Nanoparticles for PET/MRI/optical Imaging

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2022 May 9

PMID 35528689

Authors

Vivek Thakare

Vu-Long Tran

Marco Natuzzi

Eloise Thomas

Mathieu Moreau

Anthony Romieu

Bertrand Collin

Alan Courteau

Jean-Marc Vrigneaud

Cedric Louis

Stephane Roux

Frederic Boschetti

Olivier Tillement

Francois Lux

Franck Denat

Affiliations

Soon will be listed here.

Abstract

A novel trifunctional imaging probe containing a chelator of radiometal for PET, a NIR heptamethine cyanine dye, and a bioconjugatable handle, has been grafted onto AGuIX® nanoparticles a Michael addition reaction. The resulting functionalized nanoparticles have been fully characterized, radiolabelled with Cu, and evaluated in a mice TSA tumor model using multimodal (PET/MRI/optical) imaging.

Citing Articles

Recent Advances in Cu/Cu-Based Radiopharmaceuticals.

Krasnovskaya O, Abramchuck D, Erofeev A, Gorelkin P, Kuznetsov A, Shemukhin A Int J Mol Sci. 2023; 24(11).

PMID: 37298101 PMC: 10288943. DOI: 10.3390/ijms24119154.

Radiolabeled nanomaterials for biomedical applications: radiopharmacy in the era of nanotechnology.

Pijeira M, Viltres H, Kozempel J, Sakmar M, Vlk M, Ilem-Ozdemir D EJNMMI Radiopharm Chem. 2022; 7(1):8.

PMID: 35467307 PMC: 9038981. DOI: 10.1186/s41181-022-00161-4.

Dual-Labelling Strategies for Nuclear and Fluorescence Molecular Imaging: Current Status and Future Perspectives.

Kubeil M, Martinez I, Bachmann M, Kopka K, Tuck K, Stephan H Pharmaceuticals (Basel). 2022; 15(4).

PMID: 35455430 PMC: 9028399. DOI: 10.3390/ph15040432.

Advanced Optical Imaging-Guided Nanotheranostics towards Personalized Cancer Drug Delivery.

Murar M, Albertazzi L, Pujals S Nanomaterials (Basel). 2022; 12(3).

PMID: 35159744 PMC: 8838478. DOI: 10.3390/nano12030399.

Targeted PET/MRI Imaging Super Probes: A Critical Review of Opportunities and Challenges.

Kastelik-Hryniewiecka A, Jewula P, Bakalorz K, Kramer-Marek G, Kuznik N Int J Nanomedicine. 2022; 16:8465-8483.

PMID: 35002239 PMC: 8733213. DOI: 10.2147/IJN.S336299.

References

Pichler B, Judenhofer M, Pfannenberg C . Multimodal imaging approaches: PET/CT and PET/MRI. Handb Exp Pharmacol. 2008; (185 Pt 1):109-32. DOI: 10.1007/978-3-540-72718-7_6. View

Li X, Zhang X, Li X, Chang J . Multimodality imaging in nanomedicine and nanotheranostics. Cancer Biol Med. 2016; 13(3):339-348. PMC: 5069837. DOI: 10.20892/j.issn.2095-3941.2016.0055. View

Bouziotis P, Stellas D, Thomas E, Truillet C, Tsoukalas C, Lux F . Ga-radiolabeled AGuIX nanoparticles as dual-modality imaging agents for PET/MRI-guided radiation therapy. Nanomedicine (Lond). 2017; 12(13):1561-1574. DOI: 10.2217/nnm-2017-0032. View

Thorp-Greenwood F, Coogan M . Multimodal radio- (PET/SPECT) and fluorescence imaging agents based on metallo-radioisotopes: current applications and prospects for development of new agents. Dalton Trans. 2011; 40(23):6129-43. DOI: 10.1039/c0dt01398f. View

Anderson C, Ferdani R . Copper-64 radiopharmaceuticals for PET imaging of cancer: advances in preclinical and clinical research. Cancer Biother Radiopharm. 2009; 24(4):379-93. PMC: 2794299. DOI: 10.1089/cbr.2009.0674. View

Jennings L, Long N . 'Two is better than one'--probes for dual-modality molecular imaging. Chem Commun (Camb). 2009; (24):3511-24. DOI: 10.1039/b821903f. View

Maindron N, Ipuy M, Bernhard C, Lhenry D, Moreau M, Carme S . Near-Infrared-Emitting BODIPY-trisDOTA(111) In as a Monomolecular Multifunctional Imaging Probe: From Synthesis to In Vivo Investigations. Chemistry. 2016; 22(36):12670-4. DOI: 10.1002/chem.201602886. View

Le Duc G, Roux S, Paruta-Tuarez A, Dufort S, Brauer E, Marais A . Advantages of gadolinium based ultrasmall nanoparticles vs molecular gadolinium chelates for radiotherapy guided by MRI for glioma treatment. Cancer Nanotechnol. 2015; 5(1):4. PMC: 4631720. DOI: 10.1186/s12645-014-0004-8. View

Wang L, Jin J, Chen X, Fan H, Li B, Cheah K . A cyanine based fluorophore emitting both single photon near-infrared fluorescence and two-photon deep red fluorescence in aqueous solution. Org Biomol Chem. 2012; 10(28):5366-70. DOI: 10.1039/c2ob25619c. View

10.

Huynh E, Zheng G . Engineering multifunctional nanoparticles: all-in-one versus one-for-all. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2013; 5(3):250-65. DOI: 10.1002/wnan.1217. View

11.

Lhenry D, Larrouy M, Bernhard C, Goncalves V, Raguin O, Provent P . BODIPY: A Highly Versatile Platform for the Design of Bimodal Imaging Probes. Chemistry. 2015; 21(37):13091-9. DOI: 10.1002/chem.201501676. View

12.

Sancey L, Kotb S, Truillet C, Appaix F, Marais A, Thomas E . Long-term in vivo clearance of gadolinium-based AGuIX nanoparticles and their biocompatibility after systemic injection. ACS Nano. 2015; 9(3):2477-88. DOI: 10.1021/acsnano.5b00552. View

13.

Gourni E, Canovas C, Goncalves V, Denat F, Meyer P, Maecke H . (R)-NODAGA-PSMA: A Versatile Precursor for Radiometal Labeling and Nuclear Imaging of PSMA-Positive Tumors. PLoS One. 2015; 10(12):e0145755. PMC: 4689406. DOI: 10.1371/journal.pone.0145755. View

14.

Choi H, Liu W, Misra P, Tanaka E, Zimmer J, Ipe B . Renal clearance of quantum dots. Nat Biotechnol. 2007; 25(10):1165-70. PMC: 2702539. DOI: 10.1038/nbt1340. View

15.

Burke B, Cawthorne C, Archibald S . Multimodal nanoparticle imaging agents: design and applications. Philos Trans A Math Phys Eng Sci. 2017; 375(2107). DOI: 10.1098/rsta.2017.0261. View

16.

Truillet C, Bouziotis P, Tsoukalas C, Brugiere J, Martini M, Sancey L . Ultrasmall particles for Gd-MRI and (68) Ga-PET dual imaging. Contrast Media Mol Imaging. 2014; 10(4):309-19. DOI: 10.1002/cmmi.1633. View

17.

Cusin F, Fernandes Azevedo L, Bonnaventure P, Desmeules J, Daali Y, Pastor C . Hepatocyte Concentrations of Indocyanine Green Reflect Transfer Rates Across Membrane Transporters. Basic Clin Pharmacol Toxicol. 2016; 120(2):171-178. DOI: 10.1111/bcpt.12671. View

18.

Louie A . Multimodality imaging probes: design and challenges. Chem Rev. 2010; 110(5):3146-95. PMC: 2878382. DOI: 10.1021/cr9003538. View

19.

Patonay G, Salon J, Sowell J, Strekowski L . Noncovalent labeling of biomolecules with red and near- infrared dyes. Molecules. 2007; 9(3):40-9. PMC: 6147306. DOI: 10.3390/90300040. View

20.

Lux F, Tran V, Thomas E, Dufort S, Rossetti F, Martini M . AGuIX from bench to bedside-Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine. Br J Radiol. 2018; 92(1093):20180365. PMC: 6435081. DOI: 10.1259/bjr.20180365. View