Protective Effect of Ginger () Against PCB-induced Acute Hepatotoxicity in Male Rats

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2022 May 9

PMID 35528415

Authors

Khedher Ahd

Sabah Dhibi

Sarra Akermi

Hafsia Bouzenna

Noura Samout

Abdelfattah Elfeki

Najla Hfaiedh

Affiliations

Soon will be listed here.

Abstract

After absorption by the organism, polychlorinated biphenyls (PCBs) cross cellular membranes and pass into blood vessels and the lymphatic system. It is generally in the liver, adipose tissues, brain and skin that we find the strongest concentrations of PCBs. Herbal medicine remains as a discipline intended to treat and to prevent certain functional disorders and/or pathologies caused by oxidative stress, which can be induced by pesticides, medicines or pollutants. The objective of this study is to verify the toxic and oxidative effects of PCBs and to investigate the protective effect of ginger () in the liver of male rats of the "Wistar" strain. These rats are divided into 6 groups: a control group (T), two groups treated with PCB at two different concentrations (P and P), a group treated with ginger extract (G), a group pretreated with ginger extract and then injected with the first concentration of PCBs (PG), and a group pretreated with ginger and then injected with the second concentration of PCBs (PG). The results showed that the administration of PCBs led to an increase in the relative weight of the liver, and a significant increase in all of the hepatic biomarker levels (glucose, cholesterol, triglycerides, AST, ALT, and LDH) in the serum. Furthermore, an increase in the rate of lipid peroxidation and a decrease in the antioxidant enzyme activities (catalase, superoxide dismutase and glutathione peroxidase) were observed under the influence of PCBs in the liver. The histological test showed that the PCBs induced hepatocyte vacuolization, prominent and peripheralized nuclei, hepatocellular hypertrophy and turgor of the vein in the centriacinar regions. Pretreatment with ginger extract restored all of the biochemical and oxidative parameters to the normal values and reduced the injuries caused by the PCBs. In conclusion, in our experimental conditions, ginger effectively protects the liver against the hepatotoxic effects induced by PCBs.

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