Osteoblast Derived Exosomes Alleviate Radiation- Induced Hematopoietic Injury

Overview

Journal Front Bioeng Biotechnol

Date 2022 May 9

PMID 35528209

Authors

Jianqi Xue

Ruikai Du

Shukuan Ling

Jinping Song

Xinxin Yuan

Caizhi Liu

Weijia Sun

Yuheng Li

Guohui Zhong

Yinbo Wang

Guodong Yuan

Xiaoyan Jin

Zizhong Liu

Dingsheng Zhao

Youyou Li

Wenjuan Xing

Yuanyuan Fan

Zifan Liu

Junjie Pan

Zhen Zhen

Yunzhang Zhao

Qinna Yang

Jianwei Li

Yan-Zhong Chang

Yingxian Li

Affiliations

Soon will be listed here.

Abstract

As hematopoietic stem cells can differentiate into all hematopoietic lineages, mitigating the damage to hematopoietic stem cells is important for recovery from overdose radiation injury. Cells in bone marrow microenvironment are essential for hematopoietic stem cells maintenance and protection, and many of the paracrine mediators have been discovered in shaping hematopoietic function. Several recent reports support exosomes as effective regulators of hematopoietic stem cells, but the role of osteoblast derived exosomes in hematopoietic stem cells protection is less understood. Here, we investigated that osteoblast derived exosomes could alleviate radiation damage to hematopoietic stem cells. We show that intravenous injection of osteoblast derived exosomes promoted WBC, lymphocyte, monocyte and hematopoietic stem cells recovery after irradiation significantly. By sequencing osteoblast derived exosomes derived miRNAs and verified , we identified miR-21 is involved in hematopoietic stem cells protection via targeting PDCD4. Collectively, our data demonstrate that osteoblast derived exosomes derived miR-21 is a resultful regulator to radio-protection of hematopoietic stem cells and provide a new strategy for reducing radiation induced hematopoietic injury.

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