Toward a Precision Medicine Approach for Autoimmunity

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2022 May 6

PMID 35522710

Authors

Stephan Kissler

Affiliations

Soon will be listed here.

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References

FELTON L . The significance of antigen in animal tissues. J Immunol. 1949; 61(1):107-17. View

Postigo-Fernandez J, Firdessa-Fite R, Creusot R . Preclinical evaluation of a precision medicine approach to DNA vaccination in type 1 diabetes. Proc Natl Acad Sci U S A. 2022; 119(15):e2110987119. PMC: 9169641. DOI: 10.1073/pnas.2110987119. View

Jenner E . On the Origin of the Vaccine Inoculation. Med Phys J. 2018; 5(28):505-508. PMC: 5598692. View

Dixon F, MAUER P . Immunologic unresponsiveness induced by protein antigens. J Exp Med. 1955; 101(3):245-57. PMC: 2136466. DOI: 10.1084/jem.101.3.245. View

Garren H, Robinson W, Krasulova E, Havrdova E, Nadj C, Selmaj K . Phase 2 trial of a DNA vaccine encoding myelin basic protein for multiple sclerosis. Ann Neurol. 2008; 63(5):611-20. DOI: 10.1002/ana.21370. View

Chataway J, Martin K, Barrell K, Sharrack B, Stolt P, Wraith D . Effects of ATX-MS-1467 immunotherapy over 16 weeks in relapsing multiple sclerosis. Neurology. 2018; 90(11):e955-e962. DOI: 10.1212/WNL.0000000000005118. View

Gottlieb P, Utz P, Robinson W, Steinman L . Clinical optimization of antigen specific modulation of type 1 diabetes with the plasmid DNA platform. Clin Immunol. 2013; 149(3):297-306. PMC: 4800754. DOI: 10.1016/j.clim.2013.08.010. View

Bot A, Smith D, Bot S, Hughes A, Wolfe T, Wang L . Plasmid vaccination with insulin B chain prevents autoimmune diabetes in nonobese diabetic mice. J Immunol. 2001; 167(5):2950-5. DOI: 10.4049/jimmunol.167.5.2950. View

Piganelli J, Mamula M, James E . The Role of β Cell Stress and Neo-Epitopes in the Immunopathology of Type 1 Diabetes. Front Endocrinol (Lausanne). 2021; 11:624590. PMC: 7930070. DOI: 10.3389/fendo.2020.624590. View

10.

Roep B, Solvason N, Gottlieb P, Abreu J, Harrison L, Eisenbarth G . Plasmid-encoded proinsulin preserves C-peptide while specifically reducing proinsulin-specific CD8⁺ T cells in type 1 diabetes. Sci Transl Med. 2013; 5(191):191ra82. PMC: 4516024. DOI: 10.1126/scitranslmed.3006103. View

11.

Robinson W, Fontoura P, Lee B, de Vegvar H, Tom J, Pedotti R . Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis. Nat Biotechnol. 2003; 21(9):1033-9. DOI: 10.1038/nbt859. View

12.

Ramshaw I, Fordham S, Bernard C, Maguire D, Cowden W, Willenborg D . DNA vaccines for the treatment of autoimmune disease. Immunol Cell Biol. 1997; 75(4):409-13. DOI: 10.1038/icb.1997.64. View

13.

COON B, An L, Whitton J, von Herrath M . DNA immunization to prevent autoimmune diabetes. J Clin Invest. 1999; 104(2):189-94. PMC: 408480. DOI: 10.1172/JCI7209. View

14.

McCullagh P . The transfer of immunological competence to rats tolerant of sheep erythrocytes with lymphocytes from normal rats. Aust J Exp Biol Med Sci. 1970; 48(4):351-67. DOI: 10.1038/icb.1970.38. View

15.

Ulmer J, Donnelly J, Parker S, Rhodes G, Felgner P, Dwarki V . Heterologous protection against influenza by injection of DNA encoding a viral protein. Science. 1993; 259(5102):1745-9. DOI: 10.1126/science.8456302. View

16.

Smith E, Peakman M . Peptide Immunotherapy for Type 1 Diabetes-Clinical Advances. Front Immunol. 2018; 9:392. PMC: 5836708. DOI: 10.3389/fimmu.2018.00392. View