Hyperpatulones A-F, Polycyclic Polyprenylated Acylphloroglucinols from and Their Cytotoxic Activities

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2022 May 6

PMID 35521187

Authors

Zhong-Nan Wu

Qian-Wen Niu

Yu-Bo Zhang

Ding Luo

Qing-Guo Li

Ying-Ying Li

Guang-Kai Kuang

Li-Jun He

Guo-Cai Wang

Yao-Lan Li

Affiliations

Soon will be listed here.

Abstract

Six new compounds, hyperpatulones A-F (1-6), along with ten additional known related derivatives (7-16), were isolated from (Guttiferae). Their structures were elucidated by extensive analysis of spectroscopic data (IR, UV, HRESIMS, 1D and 2D NMR), X-ray crystallography, electronic circular dichroism (ECD) spectroscopy and Rh(OCOCF)-induced ECD. All compounds were tested for their cytotoxic activities on human HepG-2, HeLa, MCF-7, and A549 cell lines 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Compound 5 exhibited significant cytotoxicities against HepG-2, HeLa and A549 cell lines with IC values of 9.52 ± 0.27, 11.87 ± 0.22 and 12.63 ± 0.12 μM, respectively.

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