Fused Multicyclic Polyketides with a Two-spiro-carbon Skeleton from Mangrove-derived Endophytic Fungus SCNU-F0002

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2022 May 6

PMID 35520073

Authors

Zhangyuan Yan

Jialin Li

Geting Ye

Tao Chen

Meimei Li

Yanmin Liang

Yuhua Long

Affiliations

Soon will be listed here.

Abstract

A pair of uncommon fused multicyclic polyketides with a two- spiro-carbon skeleton, (±)-isoepicolactone, (±)-1, and one new isobenzofuranone monomer (4), together with four other known biosynthetically related compounds were isolated from the fermentation of an endophytic fungus, SCNU-F0002, which was isolated from the fresh fruit of the mangrove plant . Comprehensive spectroscopic analysis, X-ray crystallography, together with calculated ECD, were employed to define the structures. The antibacterial and COX-2 inhibitory activities of the compounds (1-6) were evaluated. A possible biogenetic pathway of (±)-isoepicolactone was confirmed.

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