Fluorescence Detection of Fluorine Ions in Biological Fluids Based on Aggregation-induced Emission

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2022 May 6

PMID 35519121

Authors

Yanming Miao

Wenli Yang

Jinzhi Lv

Affiliations

Soon will be listed here.

Abstract

Traditional chemical and biological sensors developed through aggregation-induced emission (AIE) are mainly based on "Turning on" pattern of fluorescence enhancement, which often has poor selectivity and can be easily interfered with by other substances. On this basis, an AIE-based tetraphenyl ethylene (TPE) derivative (TPE-COOH) was prepared in this study and aggregated by adding Al, so as to form the TPE-COOH/Al polymer. TPE-COOH fluorescence was enhanced through AIE principle, thus realizing the "Turning on" state. F could bind to Al after the addition of F ions which would result in the decomposition of TPE-COOH/Al aggregate, dissolved state of TPE-COOH and gradual reduction of fluorescence intensity of the system, thus realizing "Turning off" state. Moreover, F ions in biological fluid were analyzed and detected through such AIE-based "Turning on-off" pattern. The linear range of this method for F detection was 3-12 μM and the detection limit was 0.9 μM.

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