Synthesis, Anti-mycobacterial and Cytotoxic Evaluation of Substituted Isoindoline-1,3-dione-4-aminoquinolines Coupled Alkyl/amide Linkers

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2022 May 6

PMID 35518673

Authors

Anu Rani

Albertus Viljoen

Matt D Johansen

Laurent Kremer

Vipan Kumar

Affiliations

Soon will be listed here.

Abstract

A series of secondary amine-substituted isoindoline-1,3-dione-4-aminoquinolines were prepared microwave heating and assayed for their anti-mycobacterial activities. The compound with a butyl chain as a spacer between the two pharmacophores and piperidine as the secondary amine component on the isoindoline ring was the most potent and non-cytotoxic among the synthesized compounds, exhibiting a minimum inhibitory concentration (MIC) of 6.25 μg mL against .

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