Sulfadiazine Hosted in MIL-53(Al) As a Biocide Topical Delivery System

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2022 May 6

PMID 35518595

Authors

Javier Aguila-Rosas

Tomas Quirino-Barreda

Gerardo Leyva-Gomez

Eduardo Gonzalez-Zamora

Ilich A Ibarra

Enrique Lima

Affiliations

Soon will be listed here.

Abstract

Sulfadiazine (SDZ), a bacteriostatic agent, was hosted in a metal-organic framework, specifically in MIL-53(Al) and modified-zinc MIL-53(Al,Zn). Materials were characterized structural, and texturally. Both hosts loaded sulfadiazine but they were differenced regarding the release of sulfadiazine. The presence of zinc plays a significant role to the modulation of sulfadiazine-MOF interactions. Release of sulfadiazine from sulfadiazine@MOFs was monitored and conditions. A kinetic release model is proposed for sulfadiazine release. Remarkably, the materials did not show cytotoxicity against eukaryote cells.

Citing Articles

Adsorption and Release of Sulfamethizole from Mesoporous Silica Nanoparticles Functionalised with Triethylenetetramine.

Carucci C, Scalas N, Porcheddu A, Piludu M, Monduzzi M, Salis A Int J Mol Sci. 2021; 22(14).

PMID: 34299286 PMC: 8304341. DOI: 10.3390/ijms22147665.

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