Copper(ii)-catalyzed Tandem Cyclization for the Synthesis of Benzo[][1,3]thiazin-2-yl Phosphonates Involving C-P and C-S Bond Formation

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2022 May 6

PMID 35518184

Authors

Yang Liu

Shijie Yao

Chaoli Wang

Yahui Zhang

Wenyan Hao

Affiliations

Soon will be listed here.

Abstract

A copper(ii)-catalyzed, high-efficiency and atom-economical synthesis of valuable organophosphorus compounds tandem cyclization of -alkynylphenyl isothiocyanates with phosphites is described. This protocol, having a good functional-group compatibility, provides a simple and direct pathway to organophosphorus heterocycles in good yields under mild conditions. The method could be efficiently scaled up to gram scale, thus providing a potential application of this cascade cyclization strategy in synthesis.

Citing Articles

I-mediated Csp-P bond formation tandem cyclization of -alkynylphenyl isothiocyanates with organophosphorus esters.

Liu Y, Wu W, Sang X, Xia Y, Fang G, Hao W RSC Adv. 2022; 12(28):18072-18076.

PMID: 35800309 PMC: 9207709. DOI: 10.1039/d2ra03072a.

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