Pattern of F-18 FDG Uptake in Colon Cancer After Bacterial Cancer Therapy Using Engineered : A Preliminary Study

Overview

Journal Mol Imaging

Publisher Sage Publications

Specialty Radiology

Date 2022 May 6

PMID 35517712

Authors

Ari Chong

Dinh-Huy Nguyen

Hyeon Sik Kim

June-Key Chung

Jung-Joon Min

Affiliations

Soon will be listed here.

Abstract

Purpose: Bacterial cancer therapy (BCT) research using engineered has increased in recent years. 2-Deoxy-2[F] fluoro-D-glucose positron emission tomography (FDG PET) is widely used in cancer patients to detect cancer, monitor treatment responses, and predict prognoses. The aim of this pilot study was to investigate FDG uptake patterns in a mouse tumor model after BCT. . BCT was performed via the intravenous injection of attenuated (SLppGpp/lux) into female mice bearing a tumor (derived from CT26 murine colon cancer cells) in the right thigh. F-FDG PET images acquired before BCT and at different time points after BCT. bioluminescence imaging confirmed bacterial presence in the tumor. The tumor volume, standardized uptake value (SUV) of FDG (SUVmax and SUVmean), early SUV reduction%, and normalized tumor volume change were analyzed.

Results: Early after BCT (1 or 2 days post-injection (dpi)), FDG tumor uptake decreased in 10 out of 11 mice and then increased at later stages. FDG uptake before BCT was correlated with normalized tumor volume change after BCT. Early FDG reduction% after BCT was correlated with normalized volume change after BCT.

Conclusions: Early after BCT, FDG tumor uptake decreased and then increased at later stages. The higher the FDG tumor uptake before BCT, the better the BCT response. FDG uptake patterns were related to tumor volume change after BCT. Therefore, FDG uptake was a good candidate for evaluating BCT.

Citing Articles

Bacterial imaging in tumour diagnosis.

Chu J, Yu X, Jiang G, Tao Y, Wu W, Han S Microb Biotechnol. 2024; 17(6):e14474.

PMID: 38808743 PMC: 11135020. DOI: 10.1111/1751-7915.14474.

Bioengineering of bacteria for cancer immunotherapy.

Nguyen D, Chong A, Hong Y, Min J Nat Commun. 2023; 14(1):3553.

PMID: 37322031 PMC: 10272223. DOI: 10.1038/s41467-023-39224-8.

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