A Biocompatible PAA-Cu-MOP Hydrogel for Wound Healing

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2022 May 6

PMID 35517077

Authors

Linlin Chen

Yu Qin

Jing Cheng

Yi Cheng

Zhixiang Lu

Xiaolan Liu

Shaoxiong Yang

Shuhan Lu

Liyan Zheng

Qiue Cao

Affiliations

Soon will be listed here.

Abstract

Wounds infected by bacteria are dangerous for human beings. However, along with the emergence of new strains and strong bacterial resistance, traditional antibiotics are unable to meet the medical needs for treating bacterial infections. Thus, new antibacterial substances with superior antimicrobial properties are urgently needed. Herein, a hydrogel containing poly acrylic acid (PAA), glycerol and Cu-MOP (named PAA-Cu-MOP hydrogel) is obtained by a facile mixing and ultrasonic procedure for wound healing treatment. This PAA-Cu-MOP hydrogel with high biocompatibility exhibits excellent wound healing behavior and is even better than the one of recombinant human epidermal growth factor. Tissue experiment results reveal that the PAA-Cu-MOP hydrogel accelerates the wound healing process by promoting angiogenesis, stimulating cell proliferation, and up-regulating cell factors.

Citing Articles

Preparation of Ultra-Small Copper Nanoparticles-Loaded Self-Healing Hydrogels with Antibacterial, Inflammation-Suppressing and Angiogenesis-Enhancing Properties for Promoting Diabetic Wound Healing.

Geng X, Liu K, Wang J, Su X, Shi Y, Zhao L Int J Nanomedicine. 2023; 18:3339-3358.

PMID: 37361387 PMC: 10289105. DOI: 10.2147/IJN.S399933.

Progress in Antibacterial Hydrogel Dressing.

Liu J, Jiang W, Xu Q, Zheng Y Gels. 2022; 8(8).

PMID: 36005104 PMC: 9407327. DOI: 10.3390/gels8080503.

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