Rh(iii)-catalyzed Spiroannulation of 3-arylquinoxalin-2(1)-ones with Alkynes: Practical Access to Spiroquinoxalinones

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2022 May 6

PMID 35516638

Authors

Yuanfei Zhang

Ting Huang

Xinghua Li

Min Zhang

Ying Song

Kelin Huang

Weiping Su

Affiliations

Soon will be listed here.

Abstract

The Rh(iii)-catalyzed synthesis of spiroquinoxalinone derivatives from 3-arylquinoxalin-2(1)-ones and alkynes a C-H functionalization/[3 + 2] annulation sequence has been developed. This method, featuring low catalyst loading, was amenable to Gram scale synthesis and tolerated a variety of functional groups and substitution patterns on the aryl rings, providing the target products in good to excellent yields.

Citing Articles

Rh-Catalyzed [3+2] Annulation of Cyclic Ketimines and Alkynyl Chloride: A Strategy for Accessing Unsymmetrically Substituted and Highly Functionalizable Indenes.

Zhao X, Fan C, He J, Luo Y Org Lett. 2022; 24(50):9169-9173.

PMID: 36503272 PMC: 9791992. DOI: 10.1021/acs.orglett.2c02717.

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