Superficial Fabrication of Gold Nanoparticles Modified CuO Nanowires Electrode for Non-enzymatic Glucose Detection

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2022 May 6

PMID 35516144

Authors

Ashwini Kumar Mishra

Bratindranath Mukherjee

Amit Kumar

Deepak Kumar Jarwal

Smrity Ratan

Chandan Kumar

Satyabrata Jit

Affiliations

Soon will be listed here.

Abstract

This paper describes a low-cost facile method to construct gold (Au) nanoparticles (NPs) modified copper oxide (CuO) nanowires (NWs) electrode on copper foil for the detection of glucose. Copper foil has been converted to aligned CuO NWs arrays by sequential formation of Cu(OH) followed by heat treatment induced phase transformation to CuO. Au NPs are deposited on CuO NWs simple reductive solution chemistry to impart high surface to volume ratio and enhanced catalytic activity of the resulting electrode. Structure, microstructure and morphology of Cu, Cu(OH) NWs, CuO NWs, and Au NPs modified CuO NWs are investigated by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The homogeneous distribution of Au NPs (average diameter ∼12 nm) on CuO NWs (average diameter 100 nm and aspect ratio ∼20) is confirmed by high-resolution transmission electron microscopy (HRTEM), scanning transmission electron microscopy (STEM) and elemental mapping. This CuO based glucose detection method gives the highest sensitivity along with the maximum linearity range. This non-enzymatic glucose sensor based on Au modified CuO NWs electrode gives broad linearity range from 0.5 μM to 5.9 mM. The sensor exhibits sensitivity of 4398.8 μA mM cm, lower detection limit of 0.5 μM, and very fast response time of ∼5 s. Properties of the proposed glucose sensor are also investigated in human blood and it is found that the sensor is highly accurate and reliable. In addition, higher sensitivity and lower detection limit confirm that this device is suitable for invasive detection in saliva and urine.

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