Pharmacotherapy of Painful Diabetic Neuropathy: A Clinical Update

Overview

Journal Sisli Etfal Hastan Tıp Bul

Specialty General Medicine

Date 2022 May 6

PMID 35515975

Authors

Cornelius Fernandez James

Shiva Tripathi

Kyriaki Karampatou

Divya V Gladston

Joseph M Pappachan

Affiliations

Soon will be listed here.

Abstract

The rising prevalence of diabetes mellitus (DM) leads on to an increase in chronic diabetic complications. Diabetic peripheral neuropathies (DPNs) are common chronic complications of diabetes. Distal symmetric polyneuropathy is the most prevalent form. Most patients with DPN will remain pain-free; however, painful DPN (PDPN) occurs in 6-34% of all DM patients and is associated with reduced health-related-quality-of-life and substantial economic burden. Symptomatic treatment of PDPN and diabetic autonomic neuropathy is the key treatment goals. Using certain patient related characteristics, subjects with PDPN can be stratified and assigned targeted therapies to produce better pain outcomes. The aim of this review is to discuss the various pathogenetic mechanisms of DPN with special reference to the mechanisms leading to PDPN and the various pharmacological and non-pharmacological therapies available for its management. Recommended pharmacological therapies include anticonvulsants, antidepressants, opioid analgesics, and topical medications.

Citing Articles

Update on Treating Painful Diabetic Peripheral Neuropathy: A Review of Current US Guidelines with a Focus on the Most Recently Approved Management Options.

Mallick-Searle T, Adler J J Pain Res. 2024; 17:1005-1028.

PMID: 38505500 PMC: 10949339. DOI: 10.2147/JPR.S442595.

Painful Peripheral Neuropathies of the Lower Limbs and/or Lower Extremities Treated with Spinal Cord Stimulation: A Systematic Review with Narrative Synthesis.

Burkey A, Chen J, Argoff C, Edgar D, Petersen E J Pain Res. 2023; 16:1607-1636.

PMID: 37229154 PMC: 10202826. DOI: 10.2147/JPR.S403715.

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