Odontogenic MSC Heterogeneity: Challenges and Opportunities for Regenerative Medicine

Overview

Journal Front Physiol

Date 2022 May 6

PMID 35514352

Authors

Yuan Chen

Zhaoyichun Zhang

Xiaoxue Yang

Anqi Liu

Shiyu Liu

Jianying Feng

Kun Xuan

Affiliations

Soon will be listed here.

Abstract

Cellular heterogeneity refers to the genetic and phenotypic differences among cells, which reflect their various fate choices, including viability, proliferation, self-renewal probability, and differentiation into different lineages. In recent years, research on the heterogeneity of mesenchymal stem cells has made some progress. Odontogenic mesenchymal stem cells share the characteristics of mesenchymal stem cells, namely, good accessibility, low immunogenicity and high stemness. In addition, they also exhibit the characteristics of vasculogenesis and neurogenesis, making them attractive for tissue engineering and regenerative medicine. However, the usage of mesenchymal stem cell subgroups differs in different diseases. Furthermore, because of the heterogeneity of odontogenic mesenchymal stem cells, their application in tissue regeneration and disease management is restricted. Findings related to the heterogeneity of odontogenic mesenchymal stem cells urgently need to be summarized, thus, we reviewed studies on odontogenic mesenchymal stem cells and their specific subpopulations, in order to provide indications for further research on the stem cell regenerative therapy.

Citing Articles

Adipose-Derived Mesenchymal Stem Cells from Arthritis Patients: Differential Modulation of CD4⁺ T Cell Activation and Cytokine Production.

Oldak M, Kurowska W, Plebanczyk M, Janicka I, Radzikowska A, Skalska U Med Sci Monit. 2024; 30:e945273.

PMID: 39543859 PMC: 11575092. DOI: 10.12659/MSM.945273.

Application of mesenchymal stem/stromal cells in periodontal regeneration: Opportunities and challenges.

Gao P, Kajiya M, Motoike S, Ikeya M, Yang J Jpn Dent Sci Rev. 2024; 60:95-108.

PMID: 38314143 PMC: 10837070. DOI: 10.1016/j.jdsr.2024.01.001.

Single cell RNA sequencing reveals mesenchymal heterogeneity and critical functions of in tooth development.

Zhang Y, Li F, Zeng X, Zou Y, Zhu B, Ye J World J Stem Cells. 2023; 15(6):589-606.

PMID: 37424952 PMC: 10324503. DOI: 10.4252/wjsc.v15.i6.589.

[To strengthen the basic and translational research of mesenchymal stem cell-based therapy for refractory wounds].

Shi C Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2022; 38(11):999-1003.

PMID: 36418256 PMC: 11821342. DOI: 10.3760/cma.j.cn501225-20220913-00405.

Biomaterials constructed for MSC-derived extracellular vesicle loading and delivery-a promising method for tissue regeneration.

Lu Y, Yang Y, Liu S, Ge S Front Cell Dev Biol. 2022; 10:898394.

PMID: 36092710 PMC: 9454000. DOI: 10.3389/fcell.2022.898394.

References

Yang X, van den Dolder J, Walboomers X, Zhang W, Bian Z, Fan M . The odontogenic potential of STRO-1 sorted rat dental pulp stem cells in vitro. J Tissue Eng Regen Med. 2007; 1(1):66-73. DOI: 10.1002/term.16. View

Liu J, Chen B, Bao J, Zhang Y, Lei L, Yan F . Macrophage polarization in periodontal ligament stem cells enhanced periodontal regeneration. Stem Cell Res Ther. 2019; 10(1):320. PMC: 6858751. DOI: 10.1186/s13287-019-1409-4. View

Sonoyama W, Liu Y, Fang D, Yamaza T, Seo B, Zhang C . Mesenchymal stem cell-mediated functional tooth regeneration in swine. PLoS One. 2006; 1:e79. PMC: 1762318. DOI: 10.1371/journal.pone.0000079. View

Perczel-Kovach K, Hegedus O, Foldes A, Sangngoen T, Kallo K, Steward M . STRO-1 positive cell expansion during osteogenic differentiation: A comparative study of three mesenchymal stem cell types of dental origin. Arch Oral Biol. 2020; 122:104995. DOI: 10.1016/j.archoralbio.2020.104995. View

Kinzler K, Bigner S, Bigner D, Trent J, Law M, OBrien S . Identification of an amplified, highly expressed gene in a human glioma. Science. 1987; 236(4797):70-3. DOI: 10.1126/science.3563490. View

Xuan K, Li B, Guo H, Sun W, Kou X, He X . Deciduous autologous tooth stem cells regenerate dental pulp after implantation into injured teeth. Sci Transl Med. 2018; 10(455). DOI: 10.1126/scitranslmed.aaf3227. View

Gronthos S, Zannettino A, Hay S, Shi S, Graves S, Kortesidis A . Molecular and cellular characterisation of highly purified stromal stem cells derived from human bone marrow. J Cell Sci. 2003; 116(Pt 9):1827-35. DOI: 10.1242/jcs.00369. View

de Almeida J, Chen P, Henry M, Diogenes A . Stem cells of the apical papilla regulate trigeminal neurite outgrowth and targeting through a BDNF-dependent mechanism. Tissue Eng Part A. 2014; 20(23-24):3089-100. PMC: 4259194. DOI: 10.1089/ten.TEA.2013.0347. View

Lv F, Tuan R, Cheung K, Leung V . Concise review: the surface markers and identity of human mesenchymal stem cells. Stem Cells. 2014; 32(6):1408-19. DOI: 10.1002/stem.1681. View

10.

Al Bahrawy M, Ghaffar K, Gamal A, El-Sayed K, Iacono V . Effect of Inflammation on Gingival Mesenchymal Stem/Progenitor Cells' Proliferation and Migration through Microperforated Membranes: An In Vitro Study. Stem Cells Int. 2020; 2020:5373418. PMC: 7054781. DOI: 10.1155/2020/5373418. View

11.

Yuan X, Pei X, Zhao Y, Tulu U, Liu B, Helms J . A Wnt-Responsive PDL Population Effectuates Extraction Socket Healing. J Dent Res. 2018; 97(7):803-809. PMC: 6728586. DOI: 10.1177/0022034518755719. View

12.

Zhao J, Faure L, Adameyko I, Sharpe P . Stem cell contributions to cementoblast differentiation in healthy periodontal ligament and periodontitis. Stem Cells. 2020; 39(1):92-102. DOI: 10.1002/stem.3288. View

13.

Ma L, Huang Z, Wu D, Kou X, Mao X, Shi S . CD146 controls the quality of clinical grade mesenchymal stem cells from human dental pulp. Stem Cell Res Ther. 2021; 12(1):488. PMC: 8404346. DOI: 10.1186/s13287-021-02559-4. View

14.

Gonmanee T, Sritanaudomchai H, Vongsavan K, Faisaikarm T, Songsaad A, White K . Neuronal differentiation of dental pulp stem cells from human permanent and deciduous teeth following coculture with rat auditory brainstem slices. Anat Rec (Hoboken). 2020; 303(11):2931-2946. DOI: 10.1002/ar.24368. View

15.

Shakiba N, White C, Lipsitz Y, Yachie-Kinoshita A, Tonge P, Hussein S . CD24 tracks divergent pluripotent states in mouse and human cells. Nat Commun. 2015; 6:7329. PMC: 4490408. DOI: 10.1038/ncomms8329. View

16.

Wang L, Liu R, Ye P, Wong C, Chen G, Zhou P . Intracellular CD24 disrupts the ARF-NPM interaction and enables mutational and viral oncogene-mediated p53 inactivation. Nat Commun. 2015; 6:5909. PMC: 4300525. DOI: 10.1038/ncomms6909. View

17.

Iohara K, Murakami M, Takeuchi N, Osako Y, Ito M, Ishizaka R . A novel combinatorial therapy with pulp stem cells and granulocyte colony-stimulating factor for total pulp regeneration. Stem Cells Transl Med. 2013; 2(7):521-33. PMC: 3697820. DOI: 10.5966/sctm.2012-0132. View

18.

Krivanek J, Soldatov R, Kastriti M, Chontorotzea T, Herdina A, Petersen J . Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth. Nat Commun. 2020; 11(1):4816. PMC: 7511944. DOI: 10.1038/s41467-020-18512-7. View

19.

Driskell R, Clavel C, Rendl M, Watt F . Hair follicle dermal papilla cells at a glance. J Cell Sci. 2011; 124(Pt 8):1179-82. PMC: 3115771. DOI: 10.1242/jcs.082446. View

20.

Thesleff I, Nieminen P . Tooth morphogenesis and cell differentiation. Curr Opin Cell Biol. 1996; 8(6):844-50. DOI: 10.1016/s0955-0674(96)80086-x. View