Medicinal, Nutritional, and Nutraceutical Potential of Sparassis Crispa S. Lat.: a Review

Overview

Journal IMA Fungus

Publisher Biomed Central

Date 2022 May 5

PMID 35513833

Authors

Neha Sharma

Ashwani Tapwal

Rachna Verma

Dinesh Kumar

Eugenie Nepovimova

Kamil Kuca

Affiliations

Soon will be listed here.

Abstract

Sparassis crispa is an edible mushroom exhibiting a wide range of medicinal properties. It is recognized for therapeutic value because of the high β-glucan content in the basidiomes. The broad range of its reported curative effects include anti-tumour, anti-cancer, immune-enhancing, hematopoietic, anti-angiogenic, anti-inflammatory, anti-diabetic, wound-healing, antioxidant, anti-coagulant, and anti-hypertensive properties. However, most of the studies are conducted on immunomodulatory and anticancer activities. Besides this, it also exhibits anti-microbial properties due to the presence of sparassol. Technology is now available for the cultivation of S. crispa on coniferous sawdust. This review is an attempt to focus on its distribution, taxonomy, chemical composition, medicinal properties, potential applications, and artificial cultivation.

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References

Bashir K, Rheu K, Kim M, Cho M . The complete mitochondrial genome of an edible mushroom, . Mitochondrial DNA B Resour. 2020; 5(1):862-863. PMC: 7748716. DOI: 10.1080/23802359.2020.1715855. View

Kim M, Seguin P, Ahn J, Kim J, Chun S, Kim E . Phenolic compound concentration and antioxidant activities of edible and medicinal mushrooms from Korea. J Agric Food Chem. 2008; 56(16):7265-70. DOI: 10.1021/jf8008553. View

Puttaraju N, Upparahalli Venkateshaiah S, Dharmesh S, Nanjaraj Urs S, Somasundaram R . Antioxidant activity of indigenous edible mushrooms. J Agric Food Chem. 2006; 54(26):9764-72. DOI: 10.1021/jf0615707. View

Wang Z, Binder M, Dai Y, Hibbett D . Phylogenetic relationships of Sparassis inferred from nuclear and mitochondrial ribosomal DNA and RNA polymerase sequences. Mycologia. 2010; 96(5):1015-29. View

Wang Z, Liu J, Zhong X, Li J, Wang X, Ji L . Rapid Characterization of Chemical Components in Edible Mushroom by UPLC-Orbitrap MS Analysis and Potential Inhibitory Effects on Allergic Rhinitis. Molecules. 2019; 24(16). PMC: 6720900. DOI: 10.3390/molecules24163014. View

Wang J, Wang H, Ng T . A peptide with HIV-1 reverse transcriptase inhibitory activity from the medicinal mushroom Russula paludosa. Peptides. 2006; 28(3):560-5. DOI: 10.1016/j.peptides.2006.10.004. View

Harada T, Miura N, Adachi Y, Nakajima M, Yadomae T, Ohno N . IFN-gamma induction by SCG, 1,3-beta-D-glucan from Sparassis crispa, in DBA/2 mice in vitro. J Interferon Cytokine Res. 2003; 22(12):1227-39. DOI: 10.1089/10799900260475759. View

Sulkowska-Ziaja K, Muszynska B, Szewczyk A . Antioxidant components of selected indigenous edible mushrooms of the obsolete order Aphyllophorales. Rev Iberoam Micol. 2014; 32(2):99-102. DOI: 10.1016/j.riam.2013.10.011. View

Kodani S, Hayashi K, Hashimoto M, Kimura T, Dombo M, Kawagishi H . New sesquiterpenoid from the mushroom Sparassis crispa. Biosci Biotechnol Biochem. 2009; 73(1):228-9. DOI: 10.1271/bbb.80595. View

10.

Yoshitomi H, Iwaoka E, Kubo M, Shibata M, Gao M . Beneficial effect of Sparassis crispa on stroke through activation of Akt/eNOS pathway in brain of SHRSP. J Nat Med. 2010; 65(1):135-41. PMC: 2999729. DOI: 10.1007/s11418-010-0475-9. View

11.

Harada T, Miura N, Adachi Y, Nakajima M, Yadomae T, Ohn N . Effect of SCG, 1,3-beta-D-glucan from Sparassis crispa on the hematopoietic response in cyclophosphamide induced leukopenic mice. Biol Pharm Bull. 2002; 25(7):931-9. DOI: 10.1248/bpb.25.931. View

12.

Nowacka-Jechalke N, Nowak R, Lemieszek M, Rzeski W, Gawlik-Dziki U, Szpakowska N . Promising Potential of Crude Polysaccharides from against Colon Cancer: An In Vitro Study. Nutrients. 2021; 13(1). PMC: 7825430. DOI: 10.3390/nu13010161. View

13.

Lowe E, Wei D, Rice P, Li C, Kalbfleisch J, Browder I . Human vascular endothelial cells express pattern recognition receptors for fungal glucans which stimulates nuclear factor kappaB activation and interleukin 8 production. Winner of the Best Paper Award from the Gold Medal Forum. Am Surg. 2002; 68(6):508-17; discussion 517-8. View

14.

Sharifi-Rad J, Butnariu M, Ezzat S, Oluwaseun Adetunji C, Imran M, Sobhani S . Mushrooms-Rich Preparations on Wound Healing: From Nutritional to Medicinal Attributes. Front Pharmacol. 2020; 11:567518. PMC: 7525158. DOI: 10.3389/fphar.2020.567518. View

15.

Harada T, Miura N, Adachi Y, Nakajima M, Yadomae T, Ohno N . Granulocyte-macrophage colony-stimulating factor (GM-CSF) regulates cytokine induction by 1,3-beta-D-glucan SCG in DBA/2 mice in vitro. J Interferon Cytokine Res. 2004; 24(8):478-89. DOI: 10.1089/1079990041689656. View

16.

Kim H, Lee S, Singh T, Choi J, Shin T, Kim S . Sparassis crispa suppresses mast cell-mediated allergic inflammation: Role of calcium, mitogen-activated protein kinase and nuclear factor-κB. Int J Mol Med. 2012; 30(2):344-50. DOI: 10.3892/ijmm.2012.1000. View

17.

Kwon A, Qiu Z, Hashimoto M, Yamamoto K, Kimura T . Effects of medicinal mushroom (Sparassis crispa) on wound healing in streptozotocin-induced diabetic rats. Am J Surg. 2008; 197(4):503-9. DOI: 10.1016/j.amjsurg.2007.11.021. View

18.

Dhalaria R, Verma R, Kumar D, Puri S, Tapwal A, Kumar V . Bioactive Compounds of Edible Fruits with Their Anti-Aging Properties: A Comprehensive Review to Prolong Human Life. Antioxidants (Basel). 2020; 9(11). PMC: 7698232. DOI: 10.3390/antiox9111123. View

19.

Nameda S, Harada T, Miura N, Adachi Y, Yadomae T, Nakajima M . Enhanced cytokine synthesis of leukocytes by a beta-glucan preparation, SCG, extracted from a medicinal mushroom, Sparassis crispa. Immunopharmacol Immunotoxicol. 2009; 25(3):321-35. DOI: 10.1081/iph-120024500. View

20.

Han J, Lee E, Gong S, Sohng J, Kang Y, Jung H . Sparassis crispa exerts anti-inflammatory activity via suppression of TLR-mediated NF-κB and MAPK signaling pathways in LPS-induced RAW264.7 macrophage cells. J Ethnopharmacol. 2018; 231:10-18. DOI: 10.1016/j.jep.2018.11.003. View