Ribosomal Proteins Induce Stem Cell-like Characteristics in Glioma Cells As an "extra-ribosomal Function"

Overview

Journal Brain Tumor Pathol

Specialties Neurology
Oncology
Pathology

Date 2022 May 4

PMID 35508789

Authors

Takuichiro Hide

Ichiyo Shibahara

Madoka Inukai

Ryota Shigeeda

Yuki Shirakawa

Hirofumi Jono

Naoki Shinojima

Akitake Mukasa

Toshihiro Kumabe

Affiliations

Soon will be listed here.

Abstract

The characteristic features of plasticity and heterogeneity in glioblastoma (GB) cells cause therapeutic difficulties. GB cells are exposed to various stimuli from the tumor microenvironment and acquire the potential to resist chemoradiotherapy. To investigate how GB cells acquire stem cell-like phenotypes, we focused on ribosomal proteins, because ribosome incorporation has been reported to induce stem cell-like phenotypes in somatic cells. Furthermore, dysregulation of ribosome biogenesis has been reported in several types of cancer. We focused on ribosomal protein S6, which promotes sphere-forming ability and stem cell marker expression in GB cells. We expect that investigation of dysregulation of ribosome biogenesis and extra-ribosomal function in GB will provide new insights about the plasticity, heterogeneity, and therapeutic resistance of GB cells, which can potentially lead to revolutionary therapeutic strategies.

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