Evaluating the Role of LncRNAs in the Incidence of Cardiovascular Diseases in Androgenetic Alopecia Patients

Overview

Journal Cardiovasc Toxicol

Specialties Cardiology & Vascular Diseases
Toxicology

Date 2022 May 4

PMID 35507254

Authors

Masoumeh Roohaninasab

Shadnaz Fakhteh Yavari

Motahareh Babazadeh

Rozita Adldoosti Hagh

Mahboubeh Pazoki

Mehran Amrovani

Affiliations

Soon will be listed here.

Abstract

Hair loss occurs in patients with Androgenetic Alopecia (AGA). The pattern of hair loss is different between men and women. The main cause of hair loss is increased cell apoptosis and decreased regeneration, proliferation and differentiation processes in hair follicles. Long Non-Coding RNAs (lncRNAs) are one of the most important molecules that regulate the processes of apoptosis, regeneration, proliferation and differentiation in hair follicles. Since studies have shown that lncRNAs can be effective in the development of cardiotoxicity and induction of cardiovascular disease (CVD); so effective lncRNAs in the regulation of regeneration, proliferation, differentiation and apoptosis of hair follicles can be involved in the development of CVD in AGA patients with. Therefore, this study investigated the lncRNAs involved in increasing apoptosis and reducing the processes of regeneration, proliferation and differentiation of hair follicles. The aim of the current study was to evaluate the role of lncRNAs as a risk factor in the incidence of CVD in AGA patients; it will help to design treatment strategies by targeting signaling pathways without any cardiotoxicity complications.

Citing Articles

Androgenetic Alopecia in Men: An Update On Genetics.

Sadasivam I, Sambandam R, Kaliyaperumal D, Dileep J Indian J Dermatol. 2024; 69(3):282.

PMID: 39119311 PMC: 11305502. DOI: 10.4103/ijd.ijd_729_23.

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