Noncoding RNA-mediated Macrophage and Cancer Cell Crosstalk in Hepatocellular Carcinoma

Overview

Journal Mol Ther Oncolytics

Publisher Cell Press

Date 2022 May 4

PMID 35506150

Authors

Zhixia Zhou

Zhan Wang

Jie Gao

Zhijuan Lin

Yin Wang

Peipei Shan

MengKun Li

Tingting Zhou

Peifeng Li

Affiliations

Soon will be listed here.

Abstract

The tumor microenvironment (TME) is a well-recognized system that plays an essential role in tumor initiation, development, and progression. Intense intercellular communication between tumor cells and other cells (especially macrophages) occurs in the TME and is mediated by cell-to-cell contact and/or soluble messengers. Emerging evidence indicates that noncoding RNAs (ncRNAs) are critical regulators of the relationship between cells within the TME. In this review, we provide an update on the regulation of ncRNAs (primarily micro RNAs [miRNAs], long ncRNAs [lncRNAs], and circular RNAs [circRNAs]) in the crosstalk between macrophages and tumor cells in hepatocellular carcinoma (HCC). These ncRNAs are derived from macrophages or tumor cells and act as oncogenes or tumor suppressors, contributing to tumor progression not only by regulating the physiological and pathological processes of tumor cells but also by controlling macrophage infiltration, activation, polarization, and function. Herein, we also explore the options available for clinical therapeutic strategies targeting crosstalk-related ncRNAs to treat HCC. A better understanding of the relationship between macrophages and tumor cells mediated by ncRNAs will uncover new diagnostic biomarkers and pharmacological targets in cancer.

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