Seroprevalence of Antibodies Against SARS-CoV-2 Among Health Care Workers in a Pediatric Monographic Hospital in Madrid (Spain)

Overview

Journal Enferm Infecc Microbiol Clin (Engl Ed)

Specialties Infectious Diseases
Microbiology

Date 2022 May 2

PMID 35501285

Authors

Eva Escribano Ceruelo

Marco Antonio Espinel Ruiz

Marta Ortega Lopez-Pelaez

Barbara Fernandez Garoz

Julia Asensio Anton

Raquel Jimenez Garcia

Affiliations

Soon will be listed here.

Abstract

Introduction: As of 30 April 2020, 203.715 SARS-CoV-2 infections had been reported in Spain, 54.486 in Madrid, 21.4% were health care workers. Our objective is to determine seroprevalence of COVID-19 among workers in a monographic pediatric hospital.

Methods: Between April13 and 30, 1.523 health workers were recruited to be tested for SARS-CoV-2 serology screening (All Test®) and they answered a questionnaire with demographic, epidemiological and clinical information and previous exposure to COVID-19.

Findings: One thousand two hundred ninety two (84.8%) were tested. Positive serology (IgM and/or IgG) to SARS-CoV-2 was found in 17.2% (222/1.292), in 15.5% (201/1.292) if only IgG was considered. Median age was 44±13 years, 73% were female. The 33.8% (75/222) were asymptomatic. Eighty one had a previous positive rRT-PCR. The 14% (32/222) referred a family contact.

Conclusion: Serology prevalence for SARS-CoV-2 in workers of a pediatric hospital was higher than in general population. Many of them had an unnoticed infection.

Citing Articles

Socioeconomic and Demographic Risk Factors for SARS-CoV-2 Seropositivity Among Healthcare Workers in a UK Hospital: A Prospective Cohort Study.

Lam T, Saso A, Ortiz A, Hatcher J, Woodman M, Chandran S Clin Infect Dis. 2023; 78(3):594-602.

PMID: 37647517 PMC: 10954340. DOI: 10.1093/cid/ciad522.

References

Dacosta-Urbieta A, Rivero-Calle I, Pardo-Seco J, Redondo-Collazo L, Salas A, Gomez-Rial J . Seroprevalence of SARS-CoV-2 Among Pediatric Healthcare Workers in Spain. Front Pediatr. 2020; 8:547. PMC: 7516980. DOI: 10.3389/fped.2020.00547. View

Deeks J, Dinnes J, Takwoingi Y, Davenport C, Spijker R, Taylor-Phillips S . Antibody tests for identification of current and past infection with SARS-CoV-2. Cochrane Database Syst Rev. 2020; 6:CD013652. PMC: 7387103. DOI: 10.1002/14651858.CD013652. View

Suarez-Garcia I, Martinez de Aramayona Lopez M, Saez Vicente A, Lobo Abascal P . SARS-CoV-2 infection among healthcare workers in a hospital in Madrid, Spain. J Hosp Infect. 2020; 106(2):357-363. PMC: 7371579. DOI: 10.1016/j.jhin.2020.07.020. View

Barallat J, Fernandez-Rivas G, Quirant-Sanchez B, Gonzalez V, Dolade M, Martinez-Caceres E . Seroprevalence of SARS-CoV-2 IgG specific antibodies among healthcare workers in the Northern Metropolitan Area of Barcelona, Spain, after the first pandemic wave. PLoS One. 2020; 15(12):e0244348. PMC: 7769254. DOI: 10.1371/journal.pone.0244348. View

Lu X, Zhang L, Du H, Zhang J, Li Y, Qu J . SARS-CoV-2 Infection in Children. N Engl J Med. 2020; 382(17):1663-1665. PMC: 7121177. DOI: 10.1056/NEJMc2005073. View

Wu X, Fu B, Chen L, Feng Y . Serological tests facilitate identification of asymptomatic SARS-CoV-2 infection in Wuhan, China. J Med Virol. 2020; 92(10):1795-1796. PMC: 7264791. DOI: 10.1002/jmv.25904. View

Valdivia A, Torres I, Huntley D, Alcaraz M, Albert E, Gonzalez C . Diagnostic significance of SARS-CoV-2 IgM positive/IgG negative antibody profile in symptomatic patients with suspected COVID-19 testing negative by RT-PCR. J Infect. 2020; 82(1):e15-e16. PMC: 7445152. DOI: 10.1016/j.jinf.2020.08.028. View

Perez-Garcia F, Perez-Tanoira R, Romanyk J, Arroyo T, Gomez-Herruz P, Cuadros-Gonzalez J . Alltest rapid lateral flow immunoassays is reliable in diagnosing SARS-CoV-2 infection from 14 days after symptom onset: A prospective single-center study. J Clin Virol. 2020; 129:104473. PMC: 7255149. DOI: 10.1016/j.jcv.2020.104473. View

Moreno Borraz L, Gimenez Lopez M, Lasfuentes P, Gonzalez Perez E, Ortiz Domingo C, Bonafonte Marteles J . [Prevalence of SARS-CoV-2 coronavirus infection in patients and professional staff at a medium or long-stay hospital in Spain]. Rev Esp Geriatr Gerontol. 2020; 56(2):75-80. PMC: 7664346. DOI: 10.1016/j.regg.2020.10.005. View

10.

Nishiura H, Kobayashi T, Miyama T, Suzuki A, Jung S, Hayashi K . Estimation of the asymptomatic ratio of novel coronavirus infections (COVID-19). Int J Infect Dis. 2020; 94:154-155. PMC: 7270890. DOI: 10.1016/j.ijid.2020.03.020. View

11.

Garcia-Basteiro A, Moncunill G, Tortajada M, Vidal M, Guinovart C, Jimenez A . Seroprevalence of antibodies against SARS-CoV-2 among health care workers in a large Spanish reference hospital. Nat Commun. 2020; 11(1):3500. PMC: 7343863. DOI: 10.1038/s41467-020-17318-x. View

12.

Younes N, Al-Sadeq D, Al-Jighefee H, Younes S, Al-Jamal O, Daas H . Challenges in Laboratory Diagnosis of the Novel Coronavirus SARS-CoV-2. Viruses. 2020; 12(6). PMC: 7354519. DOI: 10.3390/v12060582. View