A Comprehensive Review on the Glucoregulatory Properties of Food-derived Bioactive Peptides

Overview

Journal Food Chem X

Date 2022 May 2

PMID 35498998

Authors

Forough Jahandideh

Stephane L Bourque

Jianping Wu

Affiliations

Soon will be listed here.

Abstract

Diabetes mellitus, a group of metabolic disorders characterized by persistent hyperglycemia, affects millions of people worldwide and is on the rise. Dietary proteins, from a wide range of food sources, are rich in bioactive peptides with antidiabetic properties. Notable examples include AGFAGDDAPR, a black tea-derived peptide, VRIRLLQRFNKRS, a β-conglycinin-derived peptide, and milk-derived peptide VPP, which have shown antidiabetic effects in diabetic rodent models through variety of pathways including improving beta-cells function, suppression of alpha-cells proliferation, inhibiting food intake, increasing portal cholecystokinin concentration, enhancing insulin signaling and glucose uptake, and ameliorating adipose tissue inflammation. Despite the immense research on glucoregulatory properties of bioactive peptides, incorporation of these bioactive peptides in functional foods or nutraceuticals is widely limited due to the existence of several challenges in the field of peptide research and commercialization. Ongoing research in this field, however, is fundamental to pave the road for this purpose.

Citing Articles

Oral Administration of the Adiponectin Receptor 1 Agonistic Dipeptide Tyr-Pro Prevents Hyperglycemia in Spontaneously Diabetic Torii Rats.

Nakamura S, Asaba S, Tanaka M, Matsui T ACS Omega. 2025; 10(1):1411-1418.

PMID: 39829448 PMC: 11740145. DOI: 10.1021/acsomega.4c09030.

Preparation and Characterization of Calcium-Chelated Sea Cucumber Ovum Hydrolysate and the Inhibitory Effect on α-Amylase.

Yan X, Fan F, Qin Z, Zhang L, Guan S, Han S Foods. 2025; 13(24.

PMID: 39767061 PMC: 11675376. DOI: 10.3390/foods13244119.

Bioactive Milk Peptides as a Nutraceutical Opportunity and Challenges.

Kapoor D, Gaur M, Kumar A, Ansari M, Prajapati B Curr Protein Pept Sci. 2024; 26(1):41-56.

PMID: 39171470 DOI: 10.2174/0113892037319188240806074731.

Glucoregulatory Properties of a Protein Hydrolysate from Atlantic Salmon (): Preliminary Characterization and Evaluation of DPP-IV Inhibition and Direct Glucose Uptake In Vitro.

Bjerknes C, Wubshet S, Ronning S, Afseth N, Currie C, Framroze B Mar Drugs. 2024; 22(4).

PMID: 38667768 PMC: 11050766. DOI: 10.3390/md22040151.

Identification and characterization of a calcium-binding peptide from salmon bone for the targeted inhibition of α-amylase in digestion.

Xu Z, Han S, Cui N, Liu H, Yan X, Chen H Food Chem X. 2024; 22:101352.

PMID: 38601950 PMC: 11004067. DOI: 10.1016/j.fochx.2024.101352.

References

Newsholme P, Krause M . Nutritional regulation of insulin secretion: implications for diabetes. Clin Biochem Rev. 2012; 33(2):35-47. PMC: 3387883. View

Kato M, Nakanishi T, Tani T, Tsuda T . Low-molecular fraction of wheat protein hydrolysate stimulates glucagon-like peptide-1 secretion in an enteroendocrine L cell line and improves glucose tolerance in rats. Nutr Res. 2017; 37:37-45. DOI: 10.1016/j.nutres.2016.12.002. View

FLOYD Jr J, FAJANS S, CONN J, Knopf R, Rull J . Stimulation of insulin secretion by amino acids. J Clin Invest. 1966; 45(9):1487-502. PMC: 292828. DOI: 10.1172/JCI105456. View

Zhu Y, Zhang H, Wei Y, Cai M, Gu R, Wang Y . Pea-derived peptides, VLP, LLP, VA, and LL, improve insulin resistance in HepG2 cells via activating IRS-1/PI3K/AKT and blocking ROS-mediated p38MAPK signaling. J Food Biochem. 2020; 44(11):e13454. DOI: 10.1111/jfbc.13454. View

Chandrasekaran S, Luna-Vital D, Gonzalez de Mejia E . Identification and Comparison of Peptides from Chickpea Protein Hydrolysates Using Either Bromelain or Gastrointestinal Enzymes and Their Relationship with Markers of Type 2 Diabetes and Bitterness. Nutrients. 2020; 12(12). PMC: 7765824. DOI: 10.3390/nu12123843. View

Drummond E, Flynn S, Whelan H, Nongonierma A, Holton T, Robinson A . Casein Hydrolysate with Glycemic Control Properties: Evidence from Cells, Animal Models, and Humans. J Agric Food Chem. 2018; 66(17):4352-4363. DOI: 10.1021/acs.jafc.7b05550. View

Boucher J, Kleinridders A, Kahn C . Insulin receptor signaling in normal and insulin-resistant states. Cold Spring Harb Perspect Biol. 2014; 6(1). PMC: 3941218. DOI: 10.1101/cshperspect.a009191. View

Ross S, Gulve E, Wang M . Chemistry and biochemistry of type 2 diabetes. Chem Rev. 2004; 104(3):1255-82. DOI: 10.1021/cr0204653. View

Goodpaster B, Bertoldo A, Ng J, Azuma K, Pencek R, Kelley C . Interactions among glucose delivery, transport, and phosphorylation that underlie skeletal muscle insulin resistance in obesity and type 2 Diabetes: studies with dynamic PET imaging. Diabetes. 2013; 63(3):1058-68. PMC: 3931396. DOI: 10.2337/db13-1249. View

10.

Westerterp-Plantenga M . Protein intake and energy balance. Regul Pept. 2008; 149(1-3):67-9. DOI: 10.1016/j.regpep.2007.08.026. View

11.

Noguchi N, Yanagita T, Rahman S, Ando Y . Chlorella Protein Hydrolysate Attenuates Glucose Metabolic Disorder and Fatty Liver in High-fat Diet-induced Obese Mice. J Oleo Sci. 2016; 65(7):613-20. DOI: 10.5650/jos.ess16034. View

12.

Hellstrom P . Satiety signals and obesity. Curr Opin Gastroenterol. 2013; 29(2):222-7. DOI: 10.1097/MOG.0b013e32835d9ff8. View

13.

Matsui T, Oki T, Osajima Y . Isolation and identification of peptidic alpha-glucosidase inhibitors derived from sardine muscle hydrolyzate. Z Naturforsch C J Biosci. 1999; 54(3-4):259-63. DOI: 10.1515/znc-1999-3-417. View

14.

Olagunju A, Omoba O, Enujiugha V, Alashi A, Aluko R . Thermoase-hydrolysed pigeon pea protein and its membrane fractions possess in vitro bioactive properties (antioxidative, antihypertensive, and antidiabetic). J Food Biochem. 2020; 45(3):e13429. DOI: 10.1111/jfbc.13429. View

15.

Ruderman N, Prentki M . AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome. Nat Rev Drug Discov. 2004; 3(4):340-51. DOI: 10.1038/nrd1344. View

16.

Wei Y, Zhang R, Fang L, Qin X, Cai M, Gu R . Hypoglycemic effects and biochemical mechanisms of Pea oligopeptide on high-fat diet and streptozotocin-induced diabetic mice. J Food Biochem. 2019; 43(12):e13055. DOI: 10.1111/jfbc.13055. View

17.

Soga M, Ohashi A, Taniguchi M, Matsui T, Tsuda T . The di-peptide Trp-His activates AMP-activated protein kinase and enhances glucose uptake independently of insulin in L6 myotubes. FEBS Open Bio. 2014; 4:898-904. PMC: 4223153. DOI: 10.1016/j.fob.2014.10.008. View

18.

Doi M, Yamaoka I, Nakayama M, Mochizuki S, Sugahara K, Yoshizawa F . Isoleucine, a blood glucose-lowering amino acid, increases glucose uptake in rat skeletal muscle in the absence of increases in AMP-activated protein kinase activity. J Nutr. 2005; 135(9):2103-8. DOI: 10.1093/jn/135.9.2103. View

19.

Higuchi N, Hira T, Yamada N, Hara H . Oral administration of corn zein hydrolysate stimulates GLP-1 and GIP secretion and improves glucose tolerance in male normal rats and Goto-Kakizaki rats. Endocrinology. 2013; 154(9):3089-98. DOI: 10.1210/en.2012-2275. View

20.

Jensen M, Joseph J, Ronnebaum S, Burgess S, Sherry A, Newgard C . Metabolic cycling in control of glucose-stimulated insulin secretion. Am J Physiol Endocrinol Metab. 2008; 295(6):E1287-97. PMC: 2603555. DOI: 10.1152/ajpendo.90604.2008. View