Design and / Evaluations of a Multiple-drug-containing Gingiva Disc for Periodontotherapy

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2022 May 2

PMID 35497829

Authors

Pooja Jain

Mohd Aamir Mirza

Sushama Talegaonkar

Shyamasree Nandy

Mridu Dudeja

Nilima Sharma

Md Khalid Anwer

Saad M Alshahrani

Zeenat Iqbal

Affiliations

Soon will be listed here.

Abstract

In the current work, we set out to develop and evaluate a gingiva disc of cellulose acetate phthalate and poloxamer F-127 for the simultaneous delivery of multiple drugs, namely minocycline, celecoxib, doxycycline hyclate, and simvastatin, to abolish infection, impede inflammation, avert collagen destruction, and promote alveolar bone regeneration, respectively. release studies revealed the sustained release profiles of the drugs for 12 h and that they were active against , and The bioactivity levels of these drugs were assessed by comparing the number of colony forming units during different phases of a study on Wistar rats, and the results showed a reduction in the number of bacterial colonies with the applied formulation. A mucosal irritation study conducted on Wistar rat gingiva confirmed the non-irritancy of the optimal gingiva disc. Hence, this customized, non-invasive polymeric gingiva disc displaying a sustained release of drugs can be a useful tool to treat acute to moderate stages of periodontitis.

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