Advances in Passively Driven Microfluidics and Lab-on-chip Devices: a Comprehensive Literature Review and Patent Analysis

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2022 May 2

PMID 35496619

Authors

Vigneswaran Narayanamurthy

Z E Jeroish

K S Bhuvaneshwari

Pouriya Bayat

R Premkumar

Fahmi Samsuri

Mashitah M Yusoff

Affiliations

Soon will be listed here.

Abstract

The development of passively driven microfluidic labs on chips has been increasing over the years. In the passive approach, the microfluids are usually driven and operated without any external actuators, fields, or power sources. Passive microfluidic techniques adopt osmosis, capillary action, surface tension, pressure, gravity-driven flow, hydrostatic flow, and vacuums to achieve fluid flow. There is a great need to explore labs on chips that are rapid, compact, portable, and easy to use. The evolution of these techniques is essential to meet current needs. Researchers have highlighted the vast potential in the field that needs to be explored to develop rapid passive labs on chips to suit market/researcher demands. A comprehensive review, along with patent analysis, is presented here, listing the latest advances in passive microfluidic techniques, along with the related mechanisms and applications.

Citing Articles

Quantitative investigation of a 3D bubble trapper in a high shear stress microfluidic chip using computational fluid dynamics and L*A*B* color space.

Boonsiri W, Aung H, Aswakool J, Santironnarong S, Pothipan P, Phatthanakun R Biomed Microdevices. 2025; 27(1):3.

PMID: 39800809 PMC: 11725547. DOI: 10.1007/s10544-024-00727-w.

Microfluidic Nanoparticle Separation for Precision Medicine.

Lan Z, Chen R, Zou D, Zhao C Adv Sci (Weinh). 2024; 12(4):e2411278.

PMID: 39632600 PMC: 11775552. DOI: 10.1002/advs.202411278.

Wicking pumps for microfluidics.

Aghajanloo B, Losereewanich W, Pastras C, Inglis D Biomicrofluidics. 2024; 18(6):061501.

PMID: 39494378 PMC: 11531334. DOI: 10.1063/5.0218030.

A Finger-Actuated Sample-Dosing Capillary-Driven Microfluidic Device for Loop-Mediated Isothermal Amplification.

Le X, Chan J, McMahon J, Wisniewski J, Coldham A, Alan T Biosensors (Basel). 2024; 14(9).

PMID: 39329785 PMC: 11430145. DOI: 10.3390/bios14090410.

Ensuring food safety: Microfluidic-based approaches for the detection of food contaminants.

Kasputis T, Hosmer K, He Y, Chen J Anal Sci Adv. 2024; 5(5-6):e2400003.

PMID: 38948318 PMC: 11210746. DOI: 10.1002/ansa.202400003.

References

McDonald J, Duffy D, ANDERSON J, Chiu D, Wu H, Schueller O . Fabrication of microfluidic systems in poly(dimethylsiloxane). Electrophoresis. 2000; 21(1):27-40. DOI: 10.1002/(SICI)1522-2683(20000101)21:1<27::AID-ELPS27>3.0.CO;2-C. View

Biscombe C . The Discovery of Electrokinetic Phenomena: Setting the Record Straight. Angew Chem Int Ed Engl. 2016; 56(29):8338-8340. DOI: 10.1002/anie.201608536. View

Moon B, Abbasi N, Jones S, Hwang D, Tsai S . Water-in-Water Droplets by Passive Microfluidic Flow Focusing. Anal Chem. 2016; 88(7):3982-9. DOI: 10.1021/acs.analchem.6b00225. View

Resto P, Mogen B, Wu F, Berthier E, Beebe D, Williams J . High speed droplet-based delivery system for passive pumping in microfluidic devices. J Vis Exp. 2009; (31). PMC: 3278325. DOI: 10.3791/1329. View

Kost G, Tran N, Tuntideelert M, Kulrattanamaneeporn S, Peungposop N . Katrina, the tsunami, and point-of-care testing: optimizing rapid response diagnosis in disasters. Am J Clin Pathol. 2006; 126(4):513-20. DOI: 10.1309/NWU5E6T0L4PFCBD9. View

Davey N, Neild A . Pressure-driven flow in open fluidic channels. J Colloid Interface Sci. 2011; 357(2):534-40. DOI: 10.1016/j.jcis.2011.02.022. View

Nge P, Rogers C, Woolley A . Advances in microfluidic materials, functions, integration, and applications. Chem Rev. 2013; 113(4):2550-83. PMC: 3624029. DOI: 10.1021/cr300337x. View

Lynn N, Dandy D . Passive microfluidic pumping using coupled capillary/evaporation effects. Lab Chip. 2009; 9(23):3422-9. PMC: 2827300. DOI: 10.1039/b912213c. View

Huang P, Nama N, Mao Z, Li P, Rufo J, Chen Y . A reliable and programmable acoustofluidic pump powered by oscillating sharp-edge structures. Lab Chip. 2014; 14(22):4319-23. PMC: 4198616. DOI: 10.1039/c4lc00806e. View

10.

Myers F, Lee L . Innovations in optical microfluidic technologies for point-of-care diagnostics. Lab Chip. 2008; 8(12):2015-31. DOI: 10.1039/b812343h. View

11.

Gervais L, De Rooij N, Delamarche E . Microfluidic chips for point-of-care immunodiagnostics. Adv Mater. 2011; 23(24):H151-76. DOI: 10.1002/adma.201100464. View

12.

Meyvantsson I, Warrick J, Hayes S, Skoien A, Beebe D . Automated cell culture in high density tubeless microfluidic device arrays. Lab Chip. 2008; 8(5):717-24. DOI: 10.1039/b715375a. View

13.

Iwai K, Shih K, Lin X, Brubaker T, Sochol R, Lin L . Finger-powered microfluidic systems using multilayer soft lithography and injection molding processes. Lab Chip. 2014; 14(19):3790-9. DOI: 10.1039/c4lc00500g. View

14.

Puccinelli J, Su X, Beebe D . Automated high-throughput microchannel assays for cell biology: Operational optimization and characterization. JALA Charlottesv Va. 2010; 15(1):25-32. PMC: 2830798. DOI: 10.1016/j.jala.2009.10.002. View

15.

Kuo J, Li C, Meng E . Fabrication and characterization of a microfluidic module for chemical gradient generation utilizing passive pumping. Annu Int Conf IEEE Eng Med Biol Soc. 2015; 2014:4415-8. DOI: 10.1109/EMBC.2014.6944603. View

16.

Berthier E, Beebe D . Flow rate analysis of a surface tension driven passive micropump. Lab Chip. 2007; 7(11):1475-8. DOI: 10.1039/b707637a. View

17.

Kim B, Oh S, Shin S, Yim S, Yang S, Hahn Y . Pumpless Microflow Cytometry Enabled by Viscosity Modulation and Immunobead Labeling. Anal Chem. 2018; 90(13):8254-8260. DOI: 10.1021/acs.analchem.8b01804. View

18.

Park J, Yoo S, Patel L, Lee S, Lee S . Cell morphological response to low shear stress in a two-dimensional culture microsystem with magnitudes comparable to interstitial shear stress. Biorheology. 2010; 47(3-4):165-78. DOI: 10.3233/BIR-2010-0567. View

19.

Marimuthu M, Kim S . Pumpless steady-flow microfluidic chip for cell culture. Anal Biochem. 2013; 437(2):161-3. DOI: 10.1016/j.ab.2013.02.007. View

20.

Wu L, Di Carlo D, Lee L . Microfluidic self-assembly of tumor spheroids for anticancer drug discovery. Biomed Microdevices. 2007; 10(2):197-202. DOI: 10.1007/s10544-007-9125-8. View