Biotransformation of α-terpineol by

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2022 May 2

PMID 35496018

Authors

Rui-Feng Mei

Ya-Xian Shi

Wei-He Duan

Hao Ding

Xiao-Ran Zhang

Le Cai

Zhong-Tao Ding

Affiliations

Soon will be listed here.

Abstract

α-Terpineol (1), the main volatile constituent in some traditional Chinese medicines, has been reported to be metabolized to 4-oleuropeic acid by the larvae of common cutworms. The present study verified that α-terpineol could be converted to 4-oleuropeic acid (2) and (1,2,4)--menthane-1,2,8-triol (3) by fermentation. Using shortened fermentation times, 7-hydroxy-α-terpineol (2a) was identified as an oxidative intermediate, which was consistent with the hypothesis put forward by previous studies. Cytochrome P450 enzymes were also confirmed to catalyze this biotransformation. This is the first study on the biotransformation of α-terpineol by microbial fermentation.

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