EAT Thickness As a Predominant Feature for Evaluating Arterial Stiffness in Patients with Heart Failure with Preserved Ejection Fraction

Overview

Journal Diabetes Metab Syndr Obes

Publisher Dove Medical Press

Specialty Endocrinology

Date 2022 May 2

PMID 35494532

Authors

Zhiqiang Liu

Weiwei Hu

Hanwen Zhang

Hongmei Tao

Peng Lei

Jie Liu

Yali Yu

Qian Dong

Lei Gao

Dongying Zhang

Affiliations

Soon will be listed here.

Abstract

Objective: Heart failure with preserved ejection fraction (HFpEF) is an intricacy heterogeneous syndrome. However, the association between EAT and arterial stiffness in HFpEF patients remains unknown.

Methods: A total of 102 patients were enrolled into the study, and brachial-ankle pulse-wave velocity (baPWV), epicardial adipose tissue (EAT) and body composition were assessed. Linear regression analysis was carried out to model the relationship between variables (especially EAT thickness) and baPWV.

Results: The results showed that patients with the thicker EAT fat pad (≥3.55 mm) tended to have comorbidities of hypertension, coronary artery disease (CAD), diabetes and hyperlipidemia, also with a higher level of obesity, fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), total cholesterol (TC) and triglyceride (TG). The level of baPWV was higher in EAT ≥3.55 mm group than the other group. BaPWV was positively associated with EAT, age, heart rate, waist circumference, visceral fat area, systolic and diastolic blood pressure, CRP and FBG. After adjusting for EAT, age and visceral fat area, EAT thickness (β = 0.256, P = 0.009) and visceral fat area (β = 0.229, P = 0.036) significantly associated with baPWV.

Conclusion: The study assessed for the first time that the increased EAT thickness was closely related with baPWV in HFpEF patients, suggesting patients with the thicker EAT may be independently associated with arterial stiffness under the context of HFpEF.

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References

Sueta D, Yamamoto E, Nishihara T, Tokitsu T, Fujisue K, Oike F . H2FPEF Score as a Prognostic Value in HFpEF Patients. Am J Hypertens. 2019; 32(11):1082-1090. DOI: 10.1093/ajh/hpz108. View

Borlaug B . Evaluation and management of heart failure with preserved ejection fraction. Nat Rev Cardiol. 2020; 17(9):559-573. DOI: 10.1038/s41569-020-0363-2. View

Sun Y, Si J, Li J, Dai M, King E, Zhang X . Predictive Value of HFA-PEFF Score in Patients With Heart Failure With Preserved Ejection Fraction. Front Cardiovasc Med. 2021; 8:656536. PMC: 8585787. DOI: 10.3389/fcvm.2021.656536. View

Bosy-Westphal A, Kossel E, Goele K, Blocker T, Lagerpusch M, Later W . Association of pericardial fat with liver fat and insulin sensitivity after diet-induced weight loss in overweight women. Obesity (Silver Spring). 2010; 18(11):2111-7. DOI: 10.1038/oby.2010.49. View

Homsi R, Sprinkart A, Gieseke J, Meier-Schroers M, Yuecel S, Fischer S . Cardiac magnetic resonance based evaluation of aortic stiffness and epicardial fat volume in patients with hypertension, diabetes mellitus, and myocardial infarction. Acta Radiol. 2017; 59(1):65-71. DOI: 10.1177/0284185117706201. View

Lee H, Despres J, Kon Koh K . Perivascular adipose tissue in the pathogenesis of cardiovascular disease. Atherosclerosis. 2013; 230(2):177-84. DOI: 10.1016/j.atherosclerosis.2013.07.037. View

Kim B, Kim B, Kang J . Echocardiographic epicardial fat thickness is associated with arterial stiffness. Int J Cardiol. 2012; 167(5):2234-8. DOI: 10.1016/j.ijcard.2012.06.013. View

Kawaguchi M, Hay I, Fetics B, Kass D . Combined ventricular systolic and arterial stiffening in patients with heart failure and preserved ejection fraction: implications for systolic and diastolic reserve limitations. Circulation. 2003; 107(5):714-20. DOI: 10.1161/01.cir.0000048123.22359.a0. View

Korkmaz L, Cirakoglu O, Agac M, Erkan H, Korkmaz A, Acar Z . Relation of epicardial adipose tissue with arterial compliance and stiffness in patients with hypertension. Angiology. 2013; 65(8):691-5. DOI: 10.1177/0003319713502120. View

10.

Lyle M, Brozovich F . HFpEF, a Disease of the Vasculature: A Closer Look at the Other Half. Mayo Clin Proc. 2018; 93(9):1305-1314. DOI: 10.1016/j.mayocp.2018.05.001. View

11.

Li P, Wang L, Liu C . Overweightness, obesity and arterial stiffness in healthy subjects: a systematic review and meta-analysis of literature studies. Postgrad Med. 2016; 129(2):224-230. DOI: 10.1080/00325481.2017.1268903. View

12.

Chow B, Rabkin S . The relationship between arterial stiffness and heart failure with preserved ejection fraction: a systemic meta-analysis. Heart Fail Rev. 2015; 20(3):291-303. DOI: 10.1007/s10741-015-9471-1. View

13.

Sunbul M, Agirbasli M, Durmus E, Kivrak T, Akin H, Aydin Y . Arterial stiffness in patients with non-alcoholic fatty liver disease is related to fibrosis stage and epicardial adipose tissue thickness. Atherosclerosis. 2014; 237(2):490-3. DOI: 10.1016/j.atherosclerosis.2014.10.004. View

14.

Obokata M, Reddy Y, Pislaru S, Melenovsky V, Borlaug B . Evidence Supporting the Existence of a Distinct Obese Phenotype of Heart Failure With Preserved Ejection Fraction. Circulation. 2017; 136(1):6-19. PMC: 5501170. DOI: 10.1161/CIRCULATIONAHA.116.026807. View

15.

Patel V, Shah S, Verma S, Oudit G . Epicardial adipose tissue as a metabolic transducer: role in heart failure and coronary artery disease. Heart Fail Rev. 2017; 22(6):889-902. DOI: 10.1007/s10741-017-9644-1. View

16.

Gong Y, Peng H . Correlation analysis of epicardial adipose tissue thickness, C-reactive protein, interleukin-6, visfatin, juxtaposed with another zinc finger protein 1, and type 2 diabetic macroangiopathy. Lipids Health Dis. 2021; 20(1):25. PMC: 7962295. DOI: 10.1186/s12944-021-01451-7. View

17.

Gorter T, van Woerden G, Rienstra M, Dickinson M, Hummel Y, Voors A . Epicardial Adipose Tissue and Invasive Hemodynamics in Heart Failure With Preserved Ejection Fraction. JACC Heart Fail. 2020; 8(8):667-676. DOI: 10.1016/j.jchf.2020.06.003. View

18.

Choi T, Ahmadi N, Sourayanezhad S, Zeb I, Budoff M . Relation of vascular stiffness with epicardial and pericardial adipose tissues, and coronary atherosclerosis. Atherosclerosis. 2013; 229(1):118-23. DOI: 10.1016/j.atherosclerosis.2013.03.003. View

19.

Iacobellis G . Local and systemic effects of the multifaceted epicardial adipose tissue depot. Nat Rev Endocrinol. 2015; 11(6):363-71. DOI: 10.1038/nrendo.2015.58. View

20.

Borlaug B . The pathophysiology of heart failure with preserved ejection fraction. Nat Rev Cardiol. 2014; 11(9):507-15. DOI: 10.1038/nrcardio.2014.83. View