The Role and Mechanism of MicroRNA-1224 in Human Cancer

Overview

Journal Front Oncol

Specialty Oncology

Date 2022 May 2

PMID 35494023

Authors

Mingwei Ma

Jie Li

Zimu Zhang

Juan Sun

Zhen Liu

Ziyang Zeng

Siwen Ouyang

Weiming Kang

Affiliations

Soon will be listed here.

Abstract

microRNAs (miRNAs) are a type of small endogenous non-coding RNAs composed of 20-22 nucleotides, which can regulate the expression of a gene by targeting 3' untranslated region (3'-UTR) of mRNA. Many studies have reported that miRNAs are involved in the occurrence and progression of human diseases, including malignant tumors. miR-1224 plays significant roles in different tumors, including tumor proliferation, metastasis, invasion, angiogenesis, biological metabolism, and drug resistance. Mostly, it serves as a tumor suppressor. With accumulating proofs of miR-1224, it can act as a potential bio-indicator in the diagnosis and prognosis of patients with cancer. In this article, we review the characteristics and research progress of miR-1224 and emphasize the regulation and function of miR-1224 in different cancer. Furthermore, we conclude the clinical implications of miR-1224. This review may provide new horizons for deeply understanding the role of miR-1224 as biomarkers and therapeutic targets in human cancer.

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References

Ding B, Yan L, Zhang Y, Wang Z, Zhang Y, Xia D . Analysis of the role of mutations in the KMT2D histone lysine methyltransferase in bladder cancer. FEBS Open Bio. 2019; 9(4):693-706. PMC: 6443872. DOI: 10.1002/2211-5463.12600. View

Wang M, Cui Y, Cai Y, Jiang Y, Peng Y . Comprehensive Bioinformatics Analysis of mRNA Expression Profiles and Identification of a miRNA-mRNA Network Associated with the Pathogenesis of Low-Grade Gliomas. Cancer Manag Res. 2021; 13:5135-5147. PMC: 8254561. DOI: 10.2147/CMAR.S314011. View

Mosakhani N, Lahti L, Borze I, Karjalainen-Lindsberg M, Sundstrom J, Ristamaki R . MicroRNA profiling predicts survival in anti-EGFR treated chemorefractory metastatic colorectal cancer patients with wild-type KRAS and BRAF. Cancer Genet. 2012; 205(11):545-51. DOI: 10.1016/j.cancergen.2012.08.003. View

Yang L, Wang M, He P . LncRNA NEAT1 Promotes the Progression of Gastric Cancer Through Modifying the miR-1224-5p/RSF1 Signaling Axis. Cancer Manag Res. 2020; 12:11845-11855. PMC: 7683354. DOI: 10.2147/CMAR.S267666. View

Shi Z, Wang W, Chen Y, Fan Z, Xie X, Yang L . The miR-1224-5p/TNS4/EGFR axis inhibits tumour progression in oesophageal squamous cell carcinoma. Cell Death Dis. 2020; 11(7):597. PMC: 7393493. DOI: 10.1038/s41419-020-02801-6. View

Zhang G, Wang J, Tan W, Han X, Han B, Wang H . Circular RNA EGLN3 silencing represses renal cell carcinoma progression through the miR-1224-3p/HMGXB3 axis. Acta Histochem. 2021; 123(6):151752. DOI: 10.1016/j.acthis.2021.151752. View

Velez C, Soto J, Rios K, Silva L, Hernandez W, Rivera L . Toxicity and Apoptosis Related Effects of Benzimidazo [3,2-α] Quinolinium Salts Upon Human Lymphoma Cells. Open Med Chem J. 2017; 11:54-65. PMC: 5510565. DOI: 10.2174/1874104501711010054. View

Jiang Z, Hu H, Hu W, Hou Z, Liu W, Yu Z . Circ-RNF121 regulates tumor progression and glucose metabolism by miR-1224-5p/FOXM1 axis in colorectal cancer. Cancer Cell Int. 2021; 21(1):596. PMC: 8572430. DOI: 10.1186/s12935-021-02290-3. View

Yao X, Cui X, Wu X, Xu P, Zhu W, Chen X . Tumor suppressive role of miR-1224-5p in keloid proliferation, apoptosis and invasion via the TGF-β1/Smad3 signaling pathway. Biochem Biophys Res Commun. 2017; 495(1):713-720. DOI: 10.1016/j.bbrc.2017.10.070. View

10.

Chen W, Yu Z, Huang W, Yang Y, Wang F, Huang H . LncRNA LINC00665 Promotes Prostate Cancer Progression via miR-1224-5p/SND1 Axis. Onco Targets Ther. 2020; 13:2527-2535. PMC: 7105362. DOI: 10.2147/OTT.S241578. View

11.

Jin B, Jin D, Zhuo Z, Zhang B, Chen K . MiR-1224-5p Activates Autophagy, Cell Invasion and Inhibits Epithelial-to-Mesenchymal Transition in Osteosarcoma Cells by Directly Targeting PLK1 Through PI3K/AKT/mTOR Signaling Pathway. Onco Targets Ther. 2020; 13:11807-11818. PMC: 7680192. DOI: 10.2147/OTT.S274451. View

12.

Macfarlane L, Murphy P . MicroRNA: Biogenesis, Function and Role in Cancer. Curr Genomics. 2011; 11(7):537-61. PMC: 3048316. DOI: 10.2174/138920210793175895. View

13.

Kong L, Liu P, Zheng M, Wang Z, Gao Y, Liang K . The miR-1224-5p/ELF3 Axis Regulates Malignant Behaviors of Pancreatic Cancer via PI3K/AKT/Notch Signaling Pathways. Onco Targets Ther. 2020; 13:3449-3466. PMC: 7185335. DOI: 10.2147/OTT.S248507. View

14.

Zhao R, Tian L, Zhao B, Sun Y, Cao J, Chen K . FADS1 promotes the progression of laryngeal squamous cell carcinoma through activating AKT/mTOR signaling. Cell Death Dis. 2020; 11(4):272. PMC: 7181692. DOI: 10.1038/s41419-020-2457-5. View

15.

Wang Q, Zhang R, Liu D . Long non-coding RNA ZEB1-AS1 indicates poor prognosis and promotes melanoma progression through targeting miR-1224-5p. Exp Ther Med. 2019; 17(1):857-862. PMC: 6307420. DOI: 10.3892/etm.2018.7005. View

16.

Yang S, Jiang W, Yang W, Yang C, Yang X, Chen K . Epigenetically modulated miR-1224 suppresses the proliferation of HCC through CREB-mediated activation of YAP signaling pathway. Mol Ther Nucleic Acids. 2021; 23:944-958. PMC: 7868928. DOI: 10.1016/j.omtn.2021.01.008. View

17.

Zuo Y, Shen W, Wang C, Niu N, Pu J . Circular RNA Circ-ZNF609 Promotes Lung Adenocarcinoma Proliferation by Modulating miR-1224-3p/ETV1 Signaling. Cancer Manag Res. 2020; 12:2471-2479. PMC: 7150670. DOI: 10.2147/CMAR.S232260. View

18.

Li J, Peng W, Yang P, Chen R, Gu Q, Qian W . MicroRNA-1224-5p Inhibits Metastasis and Epithelial-Mesenchymal Transition in Colorectal Cancer by Targeting SP1-Mediated NF-κB Signaling Pathways. Front Oncol. 2020; 10:294. PMC: 7083241. DOI: 10.3389/fonc.2020.00294. View

19.

Hu C, Cheng X, MingYu Q, Wang X, Shen S . The effects of microRNA-1224-5p on hepatocellular carcinoma tumor endothelial cells. J Cancer Res Ther. 2019; 15(2):329-335. DOI: 10.4103/jcrt.JCRT_40_18. View

20.

Roy S, Bantel H, Wandrer F, Schneider A, Gautheron J, Vucur M . miR-1224 inhibits cell proliferation in acute liver failure by targeting the antiapoptotic gene Nfib. J Hepatol. 2017; 67(5):966-978. DOI: 10.1016/j.jhep.2017.06.007. View