Misdiagnosis of Narcolepsy Caused by a False-positive Orexin-A/hypocretin-1 Enzyme Immune Assay

Overview

Journal J Clin Sleep Med

Specialties Neurology
Psychiatry

Date 2022 Apr 28

PMID 35481446

Authors

Tomi Sarkanen

Gabriele Sved

Maria Juujarvi

Anniina Alakuijala

Markku Partinen

Affiliations

Soon will be listed here.

Abstract

Citation: Sarkanen T, Sved G, Juujärvi M, Alakuijala A, Partinen M. Misdiagnosis of narcolepsy caused by a false-positive orexin-A/hypocretin-1 enzyme immune assay. . 2022;18(8):2075-2078.

Citing Articles

The value of using ELISA to detect orexin-A in cerebrospinal fluid in the diagnosis of narcolepsy.

Zhan Q, Deng L, Ding Y, Wang F, Han F, Zhou B Medicine (Baltimore). 2024; 103(24):e38539.

PMID: 38875396 PMC: 11175925. DOI: 10.1097/MD.0000000000038539.

Reduced CSF orexin levels in rats and patients with systemic inflammation: a preliminary study.

Ogawa Y, Shimojo N, Ishii A, Tamaoka A, Kawano S, Inoue Y BMC Res Notes. 2022; 15(1):221.

PMID: 35752867 PMC: 9233848. DOI: 10.1186/s13104-022-06121-0.

References

Dalal M, Schuld A, Haack M, Uhr M, Geisler P, Eisensehr I . Normal plasma levels of orexin A (hypocretin-1) in narcoleptic patients. Neurology. 2001; 56(12):1749-51. DOI: 10.1212/wnl.56.12.1749. View

Boddum K, Hansen M, Jennum P, Kornum B . Cerebrospinal Fluid Hypocretin-1 (Orexin-A) Level Fluctuates with Season and Correlates with Day Length. PLoS One. 2016; 11(3):e0151288. PMC: 4805193. DOI: 10.1371/journal.pone.0151288. View

Aldrich M, Chervin R, Malow B . Value of the multiple sleep latency test (MSLT) for the diagnosis of narcolepsy. Sleep. 1997; 20(8):620-9. View

Lindstrom M, Schinkelshoek M, Tienari P, Kukkonen J, Renkonen R, Fronczek R . Orexin-A measurement in narcolepsy: A stability study and a comparison of LC-MS/MS and immunoassays. Clin Biochem. 2021; 90:34-39. DOI: 10.1016/j.clinbiochem.2021.01.009. View

Hirtz C, Vialaret J, Gabelle A, Nowak N, Dauvilliers Y, Lehmann S . From radioimmunoassay to mass spectrometry: a new method to quantify orexin-A (hypocretin-1) in cerebrospinal fluid. Sci Rep. 2016; 6:25162. PMC: 4863245. DOI: 10.1038/srep25162. View

Higuchi S, Usui A, Murasaki M, Matsushita S, Nishioka N, Yoshino A . Plasma orexin-A is lower in patients with narcolepsy. Neurosci Lett. 2002; 318(2):61-4. DOI: 10.1016/s0304-3940(01)02476-4. View

Bardsen K, Gjerstad M, Partinen M, Kvivik I, Tjensvoll A, Ruoff P . Considerably Lower Levels of Hypocretin-1 in Cerebrospinal Fluid Is Revealed by a Novel Mass Spectrometry Method Compared with Standard Radioimmunoassay. Anal Chem. 2019; 91(14):9323-9329. DOI: 10.1021/acs.analchem.9b02710. View

Salomon R, Ripley B, Kennedy J, Johnson B, Schmidt D, Zeitzer J . Diurnal variation of cerebrospinal fluid hypocretin-1 (Orexin-A) levels in control and depressed subjects. Biol Psychiatry. 2003; 54(2):96-104. DOI: 10.1016/s0006-3223(02)01740-7. View

Lammers G, Bassetti C, Dolenc-Groselj L, Jennum P, Kallweit U, Khatami R . Diagnosis of central disorders of hypersomnolence: A reappraisal by European experts. Sleep Med Rev. 2020; 52:101306. DOI: 10.1016/j.smrv.2020.101306. View

10.

Mignot E, Lin L, Finn L, Lopes C, Pluff K, Sundstrom M . Correlates of sleep-onset REM periods during the Multiple Sleep Latency Test in community adults. Brain. 2006; 129(Pt 6):1609-23. DOI: 10.1093/brain/awl079. View

11.

Poli F, Overeem S, Lammers G, Plazzi G, Lecendreux M, Bassetti C . Narcolepsy as an adverse event following immunization: case definition and guidelines for data collection, analysis and presentation. Vaccine. 2012; 31(6):994-1007. DOI: 10.1016/j.vaccine.2012.12.014. View

12.

Lin L, Wisor J, Shiba T, Taheri S, Yanai K, Wurts S . Measurement of hypocretin/orexin content in the mouse brain using an enzyme immunoassay: the effect of circadian time, age and genetic background. Peptides. 2003; 23(12):2203-11. DOI: 10.1016/s0196-9781(02)00251-6. View