Synthesis of Tetrahydro-β-carbolines from 2-indolylmethyl Azides and Propargylic Alcohols

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2022 Apr 28

PMID 35479240

Authors

Haiting Yin

Qin Ma

Yushan Wang

Xiaoxia Gu

Zhijun Feng

Yunjun Wu

Ming Wang

Shaoyin Wang

Affiliations

Soon will be listed here.

Abstract

A facile and efficient route to tetrahydro-β-carbolines from 2-indolylmethyl azides and propargylic alcohols acid-catalyzed dehydrative annulation reactions is described. This reaction proceeds through a cascade sequence of Friedel-Crafts-type alkylation followed by intramolecular "Click" reaction, involving the formation of multiple chemical bonds in a single operation with excellent atom-economy and broad functional group tolerance.

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