Targeting NAD+: is It a Common Strategy to Delay Heart Aging?

Overview

Journal Cell Death Discov

Date 2022 Apr 27

PMID 35474295

Authors

Yang Yuan

Bing Liang

Xin-Lin Liu

Wen-Jing Liu

Bing-Huan Huang

Shan-Bo Yang

Yuan-Zhen Gao

Jing-Sen Meng

Meng-Jiao Li

Ting Ye

Chuan-Zhi Wang

Xiao-Kun Hu

Dong-Ming Xing

Affiliations

Soon will be listed here.

Abstract

Heart aging is the main susceptible factor to coronary heart disease and significantly increases the risk of heart failure, especially when the aging heart is suffering from ischemia-reperfusion injury. Numerous studies with NAD+ supplementations have suggested its use in anti-aging treatment. However, systematic reviews regarding the overall role of NAD+ in cardiac aging are scarce. The relationship between NAD+ signaling and heart aging has yet to be clarified. This review comprehensively summarizes the current studies on the role of NAD+ signaling in delaying heart aging from the following aspects: the influence of NAD+ supplementations on the aging heart; the relationship and cross-talks between NAD+ signaling and other cardiac aging-related signaling pathways; Importantly, the therapeutic potential of targeting NAD+ in delaying heart aging will be discussed. In brief, NAD+ plays a vital role in delaying heart aging. However, the abnormalities such as altered glucose and lipid metabolism, oxidative stress, and calcium overload could also interfere with NAD+ function in the heart. Therefore, the specific physiopathology of the aging heart should be considered before applying NAD+ supplementations. We believe that this article will help augment our understanding of heart aging mechanisms. In the meantime, it provides invaluable insights into possible therapeutic strategies for preventing age-related heart diseases in clinical settings.

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