Epitranscriptomic Dynamics in Brain Development and Disease

Overview

Journal Mol Psychiatry

Specialties Molecular Biology
Psychiatry

Date 2022 Apr 27

PMID 35474104

Authors

Andrew M Shafik

Emily G Allen

Peng Jin

Affiliations

Soon will be listed here.

Abstract

Distinct cell types are generated at specific times during brain development and are regulated by epigenetic, transcriptional, and newly emerging epitranscriptomic mechanisms. RNA modifications are known to affect many aspects of RNA metabolism and have been implicated in the regulation of various biological processes and in disease. Recent studies imply that dysregulation of the epitranscriptome may be significantly associated with neuropsychiatric, neurodevelopmental, and neurodegenerative disorders. Here we review the current knowledge surrounding the role of the RNA modifications N6-methyladenosine, 5-methylcytidine, pseudouridine, A-to-I RNA editing, 2'O-methylation, and their associated machinery, in brain development and human diseases. We also highlight the need for the development of new technologies in the pursuit of directly mapping RNA modifications in both genome- and single-molecule-level approach.

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