New Insights into Tuft Cell Formation: Implications for Structure-function Relationships

Overview

Journal Curr Opin Cell Biol

Publisher Elsevier

Specialty Cell Biology

Date 2022 Apr 25

PMID 35468541

Authors

Claire E OLeary

Zhibo Ma

Taylor Culpepper

Sammy Weiser Novak

Kathleen E DelGiorno

Affiliations

Soon will be listed here.

Abstract

Tuft cells are sentinel chemosensory cells that monitor the lumen of hollow organs for noxious or infectious stimuli and respond with disease- and tissue-specific effectors. The discovery of critical tuft cell functions in intestinal type 2 immune responses and airway defense has sparked interest in the formation and function of this architecturally unique cell type. Recent advances in single-cell transcriptomics and computational biology allow for new insights into the genetics and environmental cues underlying tuft cell formation and maturation. Here, we summarize the most recent research on tuft cell development and function in various disease states and organ systems.

Citing Articles

Intestinal tuft cell immune privilege enables norovirus persistence.

Strine M, Fagerberg E, Darcy P, Barron G, Filler R, Alfajaro M Sci Immunol. 2024; 9(93):eadi7038.

PMID: 38517952 PMC: 11555782. DOI: 10.1126/sciimmunol.adi7038.

Possible connection between intestinal tuft cells, ILC2s and obesity.

Yang H, Huang Y, Xiong P, Li J, Chen J, Liu X Front Immunol. 2024; 14:1266667.

PMID: 38283340 PMC: 10811205. DOI: 10.3389/fimmu.2023.1266667.

A single-cell atlas of in vitro multiculture systems uncovers the in vivo lineage trajectory and cell state in the human lung.

Lee W, Lee S, Yoon J, Lee D, Kim Y, Han Y Exp Mol Med. 2023; 55(8):1831-1842.

PMID: 37582976 PMC: 10474282. DOI: 10.1038/s12276-023-01076-z.

It is better to light a candle than to curse the darkness: single-cell transcriptomics sheds new light on pancreas biology and disease.

Cephas A, Hwang W, Maitra A, Parnas O, DelGiorno K Gut. 2023; 72(6):1211-1219.

PMID: 36997301 PMC: 10988578. DOI: 10.1136/gutjnl-2022-329313.

Thymic tuft cells: potential "regulators" of non-mucosal tissue development and immune response.

Sun J, Li M, Xie Y, Zhang Y, Chai Y Immunol Res. 2023; 71(4):554-564.

PMID: 36961668 PMC: 10037390. DOI: 10.1007/s12026-023-09372-6.

References

Sell E, Ortiz-Carpena J, Herbert D, Cohen N . Tuft cells in the pathogenesis of chronic rhinosinusitis with nasal polyps and asthma. Ann Allergy Asthma Immunol. 2020; 126(2):143-151. PMC: 8674819. DOI: 10.1016/j.anai.2020.10.011. View

Gerbe F, van Es J, Makrini L, Brulin B, Mellitzer G, Robine S . Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium. J Cell Biol. 2011; 192(5):767-80. PMC: 3051826. DOI: 10.1083/jcb.201010127. View

Banerjee A, Herring C, Chen B, Kim H, Simmons A, Southard-Smith A . Succinate Produced by Intestinal Microbes Promotes Specification of Tuft Cells to Suppress Ileal Inflammation. Gastroenterology. 2020; 159(6):2101-2115.e5. PMC: 7725941. DOI: 10.1053/j.gastro.2020.08.029. View

Moor A, Harnik Y, Ben-Moshe S, Massasa E, Rozenberg M, Eilam R . Spatial Reconstruction of Single Enterocytes Uncovers Broad Zonation along the Intestinal Villus Axis. Cell. 2018; 175(4):1156-1167.e15. DOI: 10.1016/j.cell.2018.08.063. View

Howitt M, Lavoie S, Michaud M, Blum A, Tran S, Weinstock J . Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut. Science. 2016; 351(6279):1329-33. PMC: 5528851. DOI: 10.1126/science.aaf1648. View

Desai P, Janova H, White J, Reynoso G, Hickman H, Baldridge M . Enteric helminth coinfection enhances host susceptibility to neurotropic flaviviruses via a tuft cell-IL-4 receptor signaling axis. Cell. 2021; 184(5):1214-1231.e16. PMC: 7962748. DOI: 10.1016/j.cell.2021.01.051. View

Yamada Y, Simon-Keller K, Belharazem-Vitacolonnna D, Bohnenberger H, Kriegsmann M, Kriegsmann K . A Tuft Cell-Like Signature Is Highly Prevalent in Thymic Squamous Cell Carcinoma and Delineates New Molecular Subsets Among the Major Lung Cancer Histotypes. J Thorac Oncol. 2021; 16(6):1003-1016. DOI: 10.1016/j.jtho.2021.02.008. View

Fang Y, Li W, Chen X . P63 Deficiency and CDX2 Overexpression Lead to Barrett's-Like Metaplasia in Mouse Esophageal Epithelium. Dig Dis Sci. 2021; 66(12):4263-4273. PMC: 8286978. DOI: 10.1007/s10620-020-06756-8. View

Fletcher R, Das D, Gadye L, Street K, Baudhuin A, Wagner A . Deconstructing Olfactory Stem Cell Trajectories at Single-Cell Resolution. Cell Stem Cell. 2017; 20(6):817-830.e8. PMC: 5484588. DOI: 10.1016/j.stem.2017.04.003. View

10.

Haber A, Biton M, Rogel N, Herbst R, Shekhar K, Smillie C . A single-cell survey of the small intestinal epithelium. Nature. 2017; 551(7680):333-339. PMC: 6022292. DOI: 10.1038/nature24489. View

11.

Middelhoff M, Nienhuser H, Valenti G, Maurer H, Hayakawa Y, Takahashi R . Prox1-positive cells monitor and sustain the murine intestinal epithelial cholinergic niche. Nat Commun. 2020; 11(1):111. PMC: 6949263. DOI: 10.1038/s41467-019-13850-7. View

12.

Herring C, Banerjee A, McKinley E, Simmons A, Ping J, Roland J . Unsupervised Trajectory Analysis of Single-Cell RNA-Seq and Imaging Data Reveals Alternative Tuft Cell Origins in the Gut. Cell Syst. 2017; 6(1):37-51.e9. PMC: 5799016. DOI: 10.1016/j.cels.2017.10.012. View

13.

Oyesola O, Shanahan M, Kanke M, Mooney B, Webb L, Smita S . PGD2 and CRTH2 counteract Type 2 cytokine-elicited intestinal epithelial responses during helminth infection. J Exp Med. 2021; 218(9). PMC: 8294949. DOI: 10.1084/jem.20202178. View

14.

Keshavarz M, Faraj Tabrizi S, Ruppert A, Pfeil U, Schreiber Y, Klein J . Cysteinyl leukotrienes and acetylcholine are biliary tuft cell cotransmitters. Sci Immunol. 2022; 7(69):eabf6734. DOI: 10.1126/sciimmunol.abf6734. View

15.

Bankova L, Barrett N . Epithelial cell function and remodeling in nasal polyposis. Ann Allergy Asthma Immunol. 2020; 124(4):333-341. PMC: 11784937. DOI: 10.1016/j.anai.2020.01.018. View

16.

Ualiyeva S, Yoshimoto E, Barrett N, Bankova L . Isolation and Quantitative Evaluation of Brush Cells from Mouse Tracheas. J Vis Exp. 2019; (148). PMC: 6830433. DOI: 10.3791/59496. View

17.

Gerbe F, Sidot E, Smyth D, Ohmoto M, Matsumoto I, Dardalhon V . Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites. Nature. 2016; 529(7585):226-30. PMC: 7614903. DOI: 10.1038/nature16527. View

18.

Gracz A, Samsa L, Fordham M, Trotier D, Zwarycz B, Lo Y . Sox4 Promotes Atoh1-Independent Intestinal Secretory Differentiation Toward Tuft and Enteroendocrine Fates. Gastroenterology. 2018; 155(5):1508-1523.e10. PMC: 6232678. DOI: 10.1053/j.gastro.2018.07.023. View

19.

OLeary C, Schneider C, Locksley R . Tuft Cells-Systemically Dispersed Sensory Epithelia Integrating Immune and Neural Circuitry. Annu Rev Immunol. 2018; 37:47-72. PMC: 8352721. DOI: 10.1146/annurev-immunol-042718-041505. View

20.

Saqui-Salces M, Keeley T, Grosse A, Qiao X, El-Zaatari M, Gumucio D . Gastric tuft cells express DCLK1 and are expanded in hyperplasia. Histochem Cell Biol. 2011; 136(2):191-204. PMC: 3570962. DOI: 10.1007/s00418-011-0831-1. View